Hospital based surveillance and molecular characterization of rotavirus in children less than 5 years of age with acute gastroenteritis in Nepal
| Autor: | Binod Man Shrestha, Sarmila Tandukar, Ganesh Kumar Rai, Jatan Bahadur Sherchan, Krishna Prasad Paudel, Ajit Rayamajhi, Jeevan B. Sherchand, Ocean Thakali, Dinesh Bhandari |
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| Rok vydání: | 2018 |
| Předmět: |
Diarrhea
Rotavirus 0301 basic medicine Pediatrics medicine.medical_specialty Genotype 030106 microbiology Enzyme-Linked Immunosorbent Assay medicine.disease_cause Rotavirus Infections Feces 03 medical and health sciences fluids and secretions 0302 clinical medicine Cost of Illness Nepal medicine Humans Public Health Surveillance 030212 general & internal medicine Genotyping General Veterinary General Immunology and Microbiology business.industry Infant Newborn Public Health Environmental and Occupational Health Infant Hospital based Acute gastroenteritis Rotavirus vaccine Gastroenteritis Hospitalization Indian subcontinent Infectious Diseases Child Preschool Acute Disease RNA Viral Molecular Medicine business Mixed infection |
| Zdroj: | Vaccine. 36:7841-7845 |
| ISSN: | 0264-410X |
| DOI: | 10.1016/j.vaccine.2018.07.044 |
| Popis: | BACKGROUND Rotavirus remains a significant causative agent of childhood acute gastroenteritis, particularly among children less than 5 years of age. Although precise data on childhood mortality associated with diarrheal disease in Nepal is not available, it is estimated that22% of all rotavirus deaths globally occurs in neighboring country of India. In spite of the substantial burden of rotavirus gastroenteritis in the Indian subcontinent, rotavirus vaccine has not been introduced in Nepal. Continuous surveillance for monitoring rotavirus disease burden and molecular characterization is needed prior to rotavirus vaccine introduction in Nepal. METHODS A total of 3310 stool samples (2849 hospitalized cases and 461 non-hospitalized cases), were collected from patients |
| Databáze: | OpenAIRE |
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