Pediatric reference intervals for alkaline phosphatase
| Autor: | Udo Steigerwald, Markus Metzler, Farhad Arzideh, Michael C. Frühwald, Jakob Zierk, Wolfgang Rascher, Rainer Haeckel, Holger Cario, Michael H. Neumann, Ralf Lichtinghagen, Thomas Streichert, Hans-Georg Ruf, Alexander Krebs, Manfred Rauh, Thomas Gscheidmeier, Hans-Jürgen Groß, Reinhard Hoffmann |
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| Rok vydání: | 2016 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Percentile Adolescent Clinical Biochemistry 030204 cardiovascular system & hematology Tertiary care 03 medical and health sciences 0302 clinical medicine Laboratory service Reference Values medicine Humans Clinical care Child business.industry Biochemistry (medical) Infant Newborn Infant General Medicine Alkaline Phosphatase Infant newborn Reference intervals Child Preschool 030220 oncology & carcinogenesis Reference values Alkaline phosphatase Female business |
| Zdroj: | Clinical Chemistry and Laboratory Medicine (CCLM). 55:102-110 |
| ISSN: | 1437-4331 1434-6621 |
| DOI: | 10.1515/cclm-2016-0318 |
| Popis: | Background: Interpretation of alkaline phosphatase activity in children is challenging due to extensive changes with growth and puberty leading to distinct sex- and age-specific dynamics. Continuous percentile charts from birth to adulthood allow accurate consideration of these dynamics and seem reasonable for an analyte as closely linked to growth as alkaline phosphatase. However, the ethical and practical challenges unique to pediatric reference intervals have restricted the creation of such percentile charts, resulting in limitations when clinical decisions are based on alkaline phosphatase activity. Methods: We applied an indirect method to generate percentile charts for alkaline phosphatase activity using clinical laboratory data collected during the clinical care of patients. A total of 361,405 samples from 124,440 patients from six German tertiary care centers and one German laboratory service provider measured between January 2004 and June 2015 were analyzed. Measurement of alkaline phosphatase activity was performed on Roche Cobas analyzers using the IFCC’s photometric method. Results: We created percentile charts for alkaline phosphatase activity in girls and boys from birth to 18 years which can be used as reference intervals. Additionally, data tables of age- and sex-specific percentile values allow the incorporation of these results into laboratory information systems. Conclusions: The percentile charts provided enable the appropriate differential diagnosis of changes in alkaline phosphatase activity due to disease and changes due to physiological development. After local validation, integration of the provided percentile charts into result reporting facilitates precise assessment of alkaline phosphatase dynamics in pediatrics. |
| Databáze: | OpenAIRE |
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