Comparison of growth factor and cytokine expression in patients with degenerated disc disease and herniated nucleus pulposus
| Autor: | Joon-Ho Wang, Kim Jm, Donggeun Sul, Lee R. Wolfer, Sun Wook Hwang, Ji-Young Lee, Seungcheol Lee, Richard Derby, Young-Ki Hong, Chan Sam Moon, Joon Sik Yoon, Min Lee, Seonyoung Choi, Sang Heon Lee, Byung Jo Kim, Juhan Kim, Minyoung Bae |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Vascular Endothelial Growth Factor A Pathology medicine.medical_specialty medicine.medical_treatment Interleukin-1beta Clinical Biochemistry Intervertebral Disc Degeneration Disease Western blot Nerve Growth Factor Humans Medicine In patient Aged medicine.diagnostic_test HERNIATED NUCLEUS PULPOSUS Interleukin-6 Tumor Necrosis Factor-alpha business.industry Growth factor Interleukin-8 General Medicine Middle Aged equipment and supplies Interleukin-12 Cytokine Disc degeneration Cytokines Intercellular Signaling Peptides and Proteins Female Spinal Diseases business Low Back Pain Intervertebral Disc Displacement Transforming growth factor |
| Zdroj: | Clinical Biochemistry. 42:1504-1511 |
| ISSN: | 0009-9120 |
| DOI: | 10.1016/j.clinbiochem.2009.06.017 |
| Popis: | Objectives This study was conducted to investigate the expression of cytokines and growth factors in disc specimens obtained from patients with herniated nucleus pulposus (HNP) and degenerated disc disease (DDD). Design and methods MRI and Western blot analyses were performed to evaluate the levels of disc degeneration and the expression levels of cytokines and growth factors. Results The levels of TNF-α and IL-8 were significantly greater in the DDD group than in the HNP group, but no statistical differences were observed in the expression of IL-1β, IL-6 and IL-12 between the HNP and DDD groups. In addition, the expression of TGF β, VEGF and NGF was significantly higher in the DDD group than in the HNP group. Conclusion The greater levels of cytokine and growth factor expression in the DDD group than in the HNP explain why discogenic patients usually have more severe back pain than patients with herniated discs. |
| Databáze: | OpenAIRE |
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