The fluoride coated AZ31B magnesium alloy improves corrosion resistance and stimulates bone formation in rabbit model
| Autor: | Wei Sun, Hong-jun Ai, Guangdao Zhang, Ke Yang, Lili Tan |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Male
Materials science Biocompatibility Bone Screws Alloy Bone Morphogenetic Protein 2 chemistry.chemical_element Bioengineering 02 engineering and technology Calcium engineering.material 010402 general chemistry 01 natural sciences Bone morphogenetic protein 2 Bone and Bones Collagen Type I Biomaterials Fluorides chemistry.chemical_compound Coated Materials Biocompatible Osteogenesis Alloys Animals Magnesium Femur Magnesium alloy Bone decalcification Metallurgy technology industry and agriculture equipment and supplies 021001 nanoscience & nanotechnology 0104 chemical sciences Corrosion Disease Models Animal Microscopy Fluorescence chemistry Mechanics of Materials Microscopy Electron Scanning engineering Rabbits 0210 nano-technology Fluoride Nuclear chemistry Titanium |
| Zdroj: | Materials Science and Engineering: C. 63:506-511 |
| ISSN: | 0928-4931 |
| DOI: | 10.1016/j.msec.2016.03.016 |
| Popis: | This study aimed to evaluate the effect of fluorine coated Mg alloy and clarify its mechanism in bone formation. We implanted the fluorine coated AZ31B Mg alloy screw (group F) in rabbit mandibular and femur in vivo. Untreated AZ31B Mg alloy screw (group A) and titanium screw (group T) were used as control. Then, scanning electron microscopy, the spectral energy distribution analysis, hard and decalcified bone tissues staining were performed. Immunohistochemistry was employed to examine the protein expressions of bone morphogenetic protein 2 (BMP-2) and collagen type I in the vicinity of the implant. Compared with the group A, the degradation of the alloy was reduced, the rates of Mg corrosion and Mg ion release were slowed down, and the depositions of calcium and phosphate increased in the group F in the early stage of implantation. Histological results showed that fluorine coated Mg alloy had well osteogenic activity and biocompatibility. Moreover, fluoride coating obviously up-regulated the expressions of collagen type I and BMP-2. This study confirmed that the fluorine coating might improve the corrosion resistance of AZ31B Mg alloy and promote bone formation by up-regulated the expressions of collagen type I and BMP-2. |
| Databáze: | OpenAIRE |
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