Altered fear learning across development in both mouse and human
| Autor: | Erika J. Ruberry, Siobhan S. Pattwell, David C. Johnson, Mark D. Elliott, Natasha Mehta, Stéphanie Duhoux, Fatima Soliman, B. J. Casey, Catherine A. Hartley, Alisa Powers, Deqiang Jing, Francis S. Lee, Charles E. Glatt, Rui R. Yang, Ipe Ninan |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Treatment response Adolescent medicine.medical_treatment Prefrontal Cortex Extinction Psychological Mice Conditioning Psychological medicine Biological neural network Animals Humans Microscopy Interference Fear learning Child Analysis of Variance Neuronal Plasticity Multidisciplinary Fear Galvanic Skin Response Extinction (psychology) Biological Sciences Anxiety Disorders Immunohistochemistry Desensitization (psychology) Synaptic plasticity Anxiety Female Analysis of variance medicine.symptom Psychology Proto-Oncogene Proteins c-fos Neuroscience |
| Zdroj: | Proceedings of the National Academy of Sciences. 109:16318-16323 |
| ISSN: | 1091-6490 0027-8424 |
| Popis: | The only evidence-based behavioral treatment for anxiety and stress-related disorders involves desensitization techniques that rely on principles of extinction learning. However, 40% of patients do not respond to this treatment. Efforts have focused on individual differences in treatment response, but have not examined when, during development, such treatments may be most effective. We examined fear-extinction learning across development in mice and humans. Parallel behavioral studies revealed attenuated extinction learning during adolescence. Probing neural circuitry in mice revealed altered synaptic plasticity of prefrontal cortical regions implicated in suppression of fear responses across development. The results suggest a lack of synaptic plasticity in the prefrontal regions, during adolescence, is associated with blunted regulation of fear extinction. These findings provide insight into optimizing treatment outcomes for when, during development, exposure therapies may be most effective. |
| Databáze: | OpenAIRE |
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