The association between adipokines and stigmata of atherosclerosis in patients with systemic lupus erythematosus
| Autor: | Habibollah Esmaily, Golnaz Gholami, Masoumeh Salari, Zahra Rezaieyazdi, Mahmoud Reza Azarpazhooh, Sima Sedighy, Zahra Mirfeizi, Asieh Karimani, Mohammad Reza Hatef |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Leptin
lcsh:Immunologic diseases. Allergy medicine.medical_specialty Homocysteine SLE Adipokine Disease Gastroenterology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Rheumatology Internal medicine medicine In patient 030212 general & internal medicine Serum adiponectin 030203 arthritis & rheumatology IMT medicine.diagnostic_test Adiponectin business.industry Atherosclerosis chemistry lcsh:RC581-607 Lipid profile business |
| Zdroj: | Egyptian Rheumatologist, Vol 42, Iss 3, Pp 195-199 (2020) |
| ISSN: | 1110-1164 |
| DOI: | 10.1016/j.ejr.2020.02.010 |
| Popis: | Aim of the work: Early cardiovascular disease is an important cause of morbidity and mortality in systemic lupus erythematosus (SLE). The study was designed to assess the relationship between the serum levels of adipokines and atherosclerotic risk factors in SLE patients. Patients and methods: 56 patients and 31 control were included. Serum levels of leptin, adiponectin, traditional and new risk factors for atherosclerosis including plasma glucose levels, lipid profile, high-sensitivity C-reactive protein (hs-CRP), vascular cell adhesion molecule-1 (VCAM-1) and homocysteine were measured. The intima-media thickness (IMT) of the carotid was measured by ultrasonography. The SLE disease activity index (SLEDAI-2k) was assessed. Results: The patients mean age was 30.8 ± 9.9 years, disease duration was 55.7 ± 59.3 months and were 54 (91.5%) females and 5 (8.5%) males. Serum adiponectin levels were significantly lower in patients (3.58 ± 0.4 ng/ml) compared to control (3.9 ± 0.26 ng/ml) (p |
| Databáze: | OpenAIRE |
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