On the Form and Origins of the Bizarre Sex Chromosomal System of the Mandarin Vole
| Autor: | Scott William Roy |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Male
X Chromosome Karyotype 03 medical and health sciences 0302 clinical medicine Intragenomic conflict Genetics Animals Inheritance Patterns Molecular Biology Genetics (clinical) X chromosome 030304 developmental biology 0303 health sciences Sex Chromosomes biology Arvicolinae Inheritance (genetic algorithm) biology.organism_classification Evolutionary biology Karyotyping Lasiopodomys mandarinus Female Vole Genomic imprinting 030217 neurology & neurosurgery Biotechnology |
| Zdroj: | Journal of Heredity. 112:328-334 |
| ISSN: | 1465-7333 0022-1503 |
| DOI: | 10.1093/jhered/esab020 |
| Popis: | Recent work has illuminated the bizarre sex chromosomal system of the mandarin vole, Lasiopodomys mandarinus. The ancestral sex chromosomes have been replaced by 4 neo-sex chromosomes. These sex chromosomes show non-Mendelian inheritance and epistatic sex determination, as well as unaccounted-for karyotype frequencies. I suggest a model to account for the complex observed inheritance patterns. The proposed model combines putative adaptations previously observed in rodents, including feminizing X chromosomes and Y-biased spermatogenesis, with a novel proposed mechanism of genomic imprinting of X-linked genes during oogenesis in XY females. Alternative possibilities are also discussed. The proposed scenario provides a relatively simple and testable model for the function and origins of a remarkably complex mammalian sex chromosomal system. |
| Databáze: | OpenAIRE |
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