Folate and Its Impact on Cancer Risk
| Autor: | Carolyn A Lammersfeld, Sharon Day, Renee Pieroth, Stephanie Paver |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty Folate Folic acid Clinical nutrition Folic Acid Deficiency 03 medical and health sciences Prostate cancer Cancer risk 0302 clinical medicine Meta-Analysis as Topic Risk Factors Diabetes mellitus Internal medicine Neoplasms Folate deficiency medicine Humans Folate intake Prospective cohort study Cancer (MF Leitzmann Section Editor) Nutrition and Dietetics biology business.industry Serum folate Folate supplementation medicine.disease 030104 developmental biology Increased risk 030220 oncology & carcinogenesis Methylenetetrahydrofolate reductase MTHFR biology.protein business SHMT Food Science |
| Zdroj: | Current Nutrition Reports |
| ISSN: | 2161-3311 |
| Popis: | Purpose of Review Research has evaluated the potential impact of folate on cancer risk with conflicting findings. Studies have demonstrated increased risk, no effect, and decreased risk. This review summarizes findings of mixed results between folate intake, serum levels, gene polymorphisms, and cancer risk based on meta-analyses from the past five years. Recent Finding Low or deficient folate status is associated with increased risk of many cancers. Folic acid supplementation and higher serum levels are associated with increased risk of prostate cancer. Gene polymorphisms may impact risk in certain ethnic groups. Summary Folate has been studied extensively due to its role in methylation and nucleotide synthesis. Further prospective studies are needed to clarify optimal levels for nutrient remediation and risk reduction in those at risk, as well as elucidate the association between high intake, high serum levels, and prostate cancer risk. Future considerations for cancer risk may include gene interactions with nutrients and environmental factors. |
| Databáze: | OpenAIRE |
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