Renal blood flow measurement by positron emission tomography using 15O-labeled water
| Autor: | Martine Lionnet, Laurent Juillard, Claude Gharib, Luc Cinotti, Maurice Laville, Didier Le Bars, Denis Fouque, Marc Janier, Paul Barthez |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Swine
Radioactive microspheres Kidney Renal Circulation Oxygen Radioisotopes medicine Animals In patient kidney blood flow Renal circulation noninvasive measurement medicine.diagnostic_test business.industry Healthy subjects Water Blood flow Angiotensin II Microspheres PET medicine.anatomical_structure Positron emission tomography Evaluation Studies as Topic Nephrology Renal blood flow oxygen 15-labeled water business Nuclear medicine Tomography Emission-Computed |
| Zdroj: | Kidney International. 57(6):2511-2518 |
| ISSN: | 0085-2538 |
| DOI: | 10.1046/j.1523-1755.2000.00110.x |
| Popis: | Renal blood flow measurement by positron emission tomography using 15O-labeled water.BackgroundOnly few noninvasive methods have the potential to quantitate renal blood flow (RBF) in humans. Positron emission tomography (PET) is a clinical imaging method that can be used to measure the tissue blood flow noninvasively. The purpose of this study was to validate PET measurement of RBF using 15O-labeled water (H215O), a tracer that allows repeated measurements at short time intervals.MethodsRBF was measured in six pigs by PET and by radioactive microspheres (MS). Three measurements were performed in each pig at baseline (BL), during vascular expansion and dopamine infusion (DA; 20 μg · kg-1 · min-1 intravenously), and during angiotensin II (Ang II) infusion (50 ng · kg-1 · min-1 intravenously). RBF was estimated from aortic and renal tracer kinetics using a model adapted from the blood flow model described by Kety and Smith.ResultsPET and MS values correlated strongly (y = 0.79x + 42, r = 0.93, P < 0.0001) over the RBF range from 100 to 500 mL · min-1 · 100 g-1. Pharmacologically induced changes were significant and were measured equally well by PET and MS: 38 and 39%, respectively, below BL (P < 0.005 and P < 0.05) under Ang II, and 47 and 48%, respectively, above BL (P < 0.005 and P < 0.01) under DA. A Bland and Altman representation showed a low average difference of -17 ± 45 mL · min-1 · 100 g-1 (mean ± SD).ConclusionTo our knowledge, this study provides the first validation of RBF measurement by PET using H215O over a large range of RBF values (100 to 500 mL · min-1 · 100 g-1), which correspond to RBF values in both healthy subjects and in patients suffering from chronic renal failure. |
| Databáze: | OpenAIRE |
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