Fluorinated PLGA Nanoparticles for Enhanced Drug Encapsulation and 19F NMR Detection
| Autor: | Pierangelo Metrangolo, Linda Chaabane, Floryan De Campo, Min Li, Francesco Cellesi, Andrea Pizzi, Giulia Neri, Roberto Gobetto, Michele R. Chierotti, Giuliana Mion, Piergiorgio Messa, Wanda Celentano, Francesca Baldelli Bombelli |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Aqueous solution
010405 organic chemistry Organic Chemistry technology industry and agriculture Nanoparticle macromolecular substances General Chemistry Fluorine-19 NMR 010402 general chemistry 01 natural sciences Combinatorial chemistry nanomedicine Catalysis 0104 chemical sciences PLGA chemistry.chemical_compound chemistry Targeted drug delivery drug delivery fluorine nanoparticles Covalent bond Drug delivery Nanomedicine |
| Popis: | In the continuous search for multimodal systems with combined diagnostic and therapeutic functions, several efforts have been made to develop multifunctional drug delivery systems. In this work, through a covalent approach, a new class of fluorinated poly(lactic-co-glycolic acid) co-polymers (F-PLGA) were designed that contain an increasing number of magnetically equivalent fluorine atoms. In particular, two novel compounds, F3 -PLGA and F9 -PLGA, were synthesized and their chemical structure and thermal stability were analyzed by solution NMR, DSC, and TGA. The obtained F-PLGA compounds were proven to form in aqueous solution colloidal stable nanoparticles (NPs) displaying a strong 19 F NMR signal. The fluorinated NPs also showed an enhanced ability to load hydrophobic drugs containing fluorine atoms compared to analogous pristine PLGA NPs. Preliminary in vitro studies showed high cell viability and the NP ability to intracellularly deliver and release a functioning drug. |
| Databáze: | OpenAIRE |
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