Estrogen levels modify scopolamine-induced amnesia in gonadally intact rats
| Autor: | Alessandra Mussi Ribeiro, Alicia Cabral, Regina H. Silva, Priscila Tavares Macêdo, André de Macêdo Medeiros, Geison S. Izídio, Diego Silveira Sousa, Anatildes Feitosa Silva, Victor Kenji M. Shiramizu |
|---|---|
| Jazyk: | angličtina |
| Předmět: |
medicine.medical_specialty
Estrous cycle phase Time Factors medicine.drug_class Scopolamine Anxiety Motor Activity Cholinergic transmission Cholinergic Antagonists Contraceptive Agents Memory Internal medicine medicine Avoidance Learning Animals Rats Wistar Maze Learning Discriminative avoidance task Biological Psychiatry Estrous cycle Pharmacology Analysis of Variance Estradiol Estradiol valerate Anxiety-like behavior Estrogens Rats Disease Models Animal Endocrinology Estrogen Ovariectomized rat Cholinergic Memory consolidation Female Amnesia Psychology hormones hormone substitutes and hormone antagonists Scopolamine Hydrobromide medicine.drug |
| Zdroj: | Progress in Neuro-Psychopharmacology and Biological Psychiatry. :99-108 |
| ISSN: | 0278-5846 |
| DOI: | 10.1016/j.pnpbp.2014.03.006 |
| Popis: | Previous studies suggested that estrogen plays a role in cognitive function by modulating the cholinergic transmission. However, most of the studies dealing with this subject have been conducted using ovariectomized rats. In the present study we evaluated the effects of physiological and supra-physiological variation of estrogen levels on scopolamine-induced amnesia in gonadally intact female rats. We used the plus-maze discriminative avoidance task (PMDAT) in order to evaluate anxiety levels and motor activity concomitantly to the memory performance. In experiment 1, female Wistar rats in each estrous cycle phase received scopolamine (1 mg/kg) or saline i.p. 20 min before the training session in the PMDAT. In experiment 2, rats in diestrus received estradiol valerate (1 mg/kg) or sesame oil i.m., and scopolamine (1 mg/kg) or saline i.p., 45 min and 20 min before the training, respectively. In experiment 3, rats in diestrus received scopolamine (1 mg/kg) or saline i.p. 20 min before the training, and estradiol valerate (1 mg/kg) or sesame oil i.m. immediately after the training session. In all experiments, a test session was performed 24 h later. The main results showed that: (1) scopolamine impaired retrieval and induced anxiolytic and hyperlocomotor effects in all experiments; (2) this cholinergic antagonist impaired acquisition only in animals in diestrus; (3) acute administration of estradiol valerate prevented the learning impairment induced by scopolamine and (4) interfered with memory consolidation process. The results suggest that endogenous variations in estrogen levels across the estrous cycle modulate some aspects of memory mediated by the cholinergic system. Indeed, specifically in diestrus, a stage with low estrogen levels, the impairment produced by scopolamine on the acquisition was counteracted by exogenous administration of the hormone, whereas the posttraining treatment potentiated the negative effects of scopolamine during the consolidation phase of memory. |
| Databáze: | OpenAIRE |
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