The effect of treadmill exercise on inflammatory responses in rat model of streptozotocin-induced experimental dementia of Alzheimer’s type
| Autor: | Hyun Sub Um, Eun Bum Kang, Hoo Seong Park, Jung eun Byun, Dong Cheol Yeom, Jung Hoon Koo, Yong Chul Jang, Joon Yong Cho, Dong Hun Choi, In Su Kwon, In-Ho Cho |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Gerontology
medicine.medical_specialty Original Paper endocrine system diseases business.industry Streptozotocin Rat model nutritional and metabolic diseases Treadmill exercise Water maze medicine.disease Animal model Endocrinology Internal medicine medicine Dementia Tumor necrosis factor alpha Treadmill Amyloid-beta business Alzheimer’s disease Inflammatory medicine.drug |
| Zdroj: | Journal of Exercise Nutrition & Biochemistry |
| ISSN: | 2233-6842 2233-6834 |
| Popis: | Dong Hun Choi, In Su Kwon, Jung Hoon Koo, Yong Chul Jang, Eun Bum Kang, Jung Eun Byun, Hyun Sub Um, Hoo SeongPark, Dong Cheol Yeom, In Ho Cho and Joon Yong Cho. The effect of treadmill exercise on inflammatory responses in ratmodel of streptozotocin-induced experimental dementia of Alzheimer`s type. JENB., Vol. 18, No. 2, pp.225-233, 2014 [Purpose]The aim of this study was to investigate the effect of treadmill exercise on inflammatory response in streptozotocin (STZ)-inducedanimal model of Alzheimer`s disease (AD). [Methods]To induce the animal model of AD, Sprague-Dawley rats were injectedinto intracerebroventricular (ICV) injection with 1.5 mg/kg of STZ. Rats were divided into three groups as Sham-con group (n= 7), STZ-con group (n = 7) and STZ-exe group (n = 7). Exercise group ran on the treadmill for 30 min/day, 5 days/week during6 weeks. [Results] The results of this study were as follows: First, STZ-exe group was improved on cognitive function whencompared to STZ-con group in water maze test. Second, STZ-exe group help reduce the expression level of amyloid-beta (Aβ). In addition, Toll-like receptors-4 (TLR4), Nuclear factor-kB (NF-kB), Tumor necrosis factor-α (TNF-α) and Interleukin-1α (IL-1α)level of STZ-exe group was significantly decreased when compared to STZ-con group. [Conclusion] These results show that treadmillexercise had positive effect on cognitive function and reduced inflammatory response in STZ-induced animal model of AD. [Keyword]Streptozotocin, Alzheimer`s disease, Treadmill exercise, Amyloid-beta, Inflammatory |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|