Deleted in breast cancer-1 (DBC-1) in the interface between metabolism, aging and cancer

Autor: Claudia Cs S. Chini, Veronica Nin, Carlos Escande, Eduardo N. Chini
Jazyk: angličtina
Rok vydání: 2013
Předmět:
DBC1
deleted in breast cancer-1
CARP1
cell division cycle and apoptosis regulator protein 1
lcsh:Life
lcsh:QR1-502
HDAC
histone deacetylase
Review Article
ACC
acetyl-CoA carboxylase
Biochemistry
lcsh:Microbiology
Epigenesis
Genetic
Histones
0302 clinical medicine
Neoplasms
Nuclear protein
Epigenesis
Regulation of gene expression
Genetics
0303 health sciences
biology
DBIRD
DBC1-ZIRD complex
histone deacetylase (HDAC)
3. Good health
Gene Expression Regulation
Neoplastic
Histone
ATR
ataxia telangiectasia and Rad3-related
030220 oncology & carcinogenesis
ESA
essential for Sirt1 activity
TR
thyroid hormone receptor
S1
ER
oestrogen receptor
deleted in breast cancer-1 (DBC1)
circadian cycle
Biophysics
Histone Deacetylases
03 medical and health sciences
CCAR1
cell cycle and apoptosis regulator 1
Breast cancer
medicine
Animals
Humans
LZ
leucine zipper
cancer
Epigenetics
Molecular Biology
030304 developmental biology
Adaptor Proteins
Signal Transducing
GR
glucocorticoid receptor
epigenetics
RNAPII
RNA polymerase II
aging
Cancer
Cell Biology
medicine.disease
AMPK
AMP-activated protein kinase
lcsh:QH501-531
NL
nuclear localization
RAR
retinoic acid receptor
Cancer cell
Cancer research
biology.protein
Spliceosomes
AR
androgen receptor
mRNP
messenger ribonucleoprotein
PKA
protein kinase A
ATM
ataxia telangiectasia-mutated
Energy Metabolism
Protein Processing
Post-Translational
metabolism
Zdroj: Bioscience Reports, Vol 33, Iss 4, p e00058 (2013)
Bioscience Reports
ISSN: 1573-4935
0144-8463
Popis: DBC1 (deleted in breast cancer-1) is a nuclear protein that regulates cellular metabolism. Since alteration in cellular metabolism have been proposed to be the emerging ‘hallmark’ of cancer, it is possible that DBC1 may be implicated in the regulation of cancer cell energy metabolism. However, at this point any role of DBC1 in cancer is only speculative. In this review, we will discuss the new developments in DBC1 research, its molecular structure, regulatory roles and implication in metabolism, aging and cancer.
Databáze: OpenAIRE
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