What can we learn from systemic lupus erythematosus pathophysiology to improve current therapy?
| Autor: | Andreia Vilas-Boas, David A. Isenberg, Jyoti Bakshi |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Clinical Trials as Topic
Systemic lupus erythematosus business.industry Mechanism (biology) Immunology Autoimmunity Disease Bioinformatics medicine.disease medicine.disease_cause Pathophysiology Biological Therapy Clinical trial Immune system Immune System Animals Humans Lupus Erythematosus Systemic Immunology and Allergy Medicine Effective treatment Molecular Targeted Therapy business |
| Zdroj: | Expert Review of Clinical Immunology. 11:1093-1107 |
| ISSN: | 1744-8409 1744-666X |
| DOI: | 10.1586/1744666x.2015.1078237 |
| Popis: | Systemic lupus erythematosus is an autoimmune disorder that can affect every organ system and cause a wide range of signs and symptoms. The precise pathogenic mechanism of disease remains uncertain, but it is clearly complex and involves the activation and deregulation of many components of the immune system. Certain well-characterized patterns of immune pathology are shared by a significant subset of patients and selective targeting of one or more of the key immune system molecules offers the prospect of more effective treatment. This review addresses the current and future treatment for patients with lupus, going from the lessons learnt with pathophysiologic studies to recent clinical trials with biological agents. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|