Suppressive effects of E3330, a novel quinone derivative, on tumor necrosis factor-α generation from monocytes and macrophages
| Autor: | Isao Yamatsu, Kouichi Katayama, Masahiro Yasuda, Kaname Miyamoto, Takashi Yamanaka, Junichi Nagakawa, Kazuo Hirota, Ieharu Hishinuma |
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| Rok vydání: | 1992 |
| Předmět: |
Lipopolysaccharides
Male medicine.medical_specialty Lipopolysaccharide Kupffer Cells medicine.medical_treatment Molecular Sequence Data Immunology Biology Toxicology Peripheral blood mononuclear cell Monocytes Mice chemistry.chemical_compound Internal medicine Benzoquinones medicine Animals Humans Macrophage Pharmacology (medical) Propionibacterium acnes Northern blot Cells Cultured Pharmacology Mice Inbred BALB C Base Sequence Tumor Necrosis Factor-alpha Macrophages Monocyte Blotting Northern Molecular biology Rats Inbred F344 Immune complex Rats Endocrinology Cytokine medicine.anatomical_structure chemistry Depression Chemical RNA Tumor necrosis factor alpha Propionates Spleen |
| Zdroj: | Agents and Actions. 37:297-304 |
| ISSN: | 1420-908X 0065-4299 |
| DOI: | 10.1007/bf02028123 |
| Popis: | E3330 [(2E)-3-[5-(2,3-dimethoxy-6-methyl-1,4-benzoquinoyl)]-2-nonyl-2- propenoic acid], a novel synthesized hepatoprotective compound, has suppressive effects on tumor necrosis factor-alpha (TNF-alpha) generation from monocytes/macrophages in vitro. E3330 (1-100 microM) reduced lipopolysaccharide (LPS, 10 mg/ml or 1 microgram/ml)-induced TNF-alpha generation from rat resident and Propionibacterium acnes (P. acnes)-elicited peritoneal macrophages, rat and human monocytes, rat Kupffer cells, and splenic mononuclear cells in a concentration-dependent manner. E3330 also (1-100 microM) suppressed TNF-alpha generation stimulated with egg-albumin immune complex in rat P. acnes-elicited peritoneal macrophages. Northern blot analysis showed that LPS-induced expression of TNF-alpha messenger RNA (mRNA) in human blood monocytes was suppressed by E3330. These findings indicate that E3330 has a suppressive effect on TNF-alpha generation from monocytes/macrophages, regardless of origin or species, and this effect is based in part on the suppression of TNF-alpha mRNA expression. |
| Databáze: | OpenAIRE |
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