A Time Course of Bevacizumab (Anti-VEGF) Effect on Rat Peritoneum: Relations Between Antiadhesive Action and Fibrin Regulation Enzymes
| Autor: | Kyriakos Psarras, Theodoros E. Pavlidis, Christina Nikolaidou, Aristotelis Lymperopoulos, Evangelia K. Siska, Aikaterini-Eftychia Micha, Ioannis Venizelos, Efthymia Vlachaki, Nikolaos Symeonidis, Odysseas Ouroumidis, George Koliakos |
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| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.medical_specialty Bevacizumab Fibrin matrix Angiogenesis Inhibitors Tissue Adhesions Pharmacology Fibrin 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine Plasminogen Activator Inhibitor 1 medicine Animals Rats Wistar skin and connective tissue diseases Cecum chemistry.chemical_classification Anti vegf biology business.industry Fibrinolysis Rat Peritoneum Rats Vascular endothelial growth factor Endocrinology Enzyme chemistry Matrix Metalloproteinase 9 030220 oncology & carcinogenesis Tissue Plasminogen Activator Time course biology.protein 030211 gastroenterology & hepatology Surgery sense organs Peritoneum business medicine.drug |
| Zdroj: | Surgical innovation. 24(6) |
| ISSN: | 1553-3514 |
| Popis: | To investigate the early and late antiadhesive effect and any changes of fibrin matrix regulation enzymes on rat peritoneum, after local administration of bevacizumab.Rats were subjected to cecal abrasion. Bevacizumab (5 mg/kg) against placebo was given intraperitoneally. On the 2nd, 14th, and 28th postoperative days adhesions were scored, and tissue plasminogen activator (tPA), plasminogen activator inhibitor-1 (PAI-1), matrix metalloproteinase-9 (MMP-9), degree of fibrosis, and angiogenesis were measured in abrased cecum and in intact parietal peritoneum.Bevacizumab significantly reduced adhesions up to 15% on the 2nd, 52.5% on the 14th, and 55% on the 28th postoperative day, and significantly increased tPA concentrations in peritoneum. PAI-1 was decreased, and a significantly higher tPA/PAI-1 ratio along with an increase of MMP-9 was measured at all time points. Fibrosis and angiogenesis were significantly lower on the 14th and 28th postoperative days.Local bevacizumab administration has a strong early and late antiadhesive action on rat peritoneum, mediated by changes in the tPA/PAI-1 and MMP balance in favor of fibrinolysis up to 28 days after operations. |
| Databáze: | OpenAIRE |
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