Inflammation and Oxidative Stress in Deficit Schizophrenia
| Autor: | Altan Eşsizoğlu, Sinem Sevİl DeĞİrmencİ, Gülcan Güleç, Ferdi Köşger, Reyhan DaĞ KarataŞ, Semra Yiğitaslan |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
business.industry General Neuroscience medicine.medical_treatment Interleukin Inflammation medicine.disease medicine.disease_cause PON1 Proinflammatory cytokine Psychiatry and Mental health Endocrinology Cytokine Schizophrenia Internal medicine medicine Tumor necrosis factor alpha medicine.symptom business Oxidative stress Research Article |
| Zdroj: | Noro Psikiyatr Ars |
| Popis: | Introduction Differences in parameters related to inflammatory and oxidative stress in deficit (DS) and nondeficit schizophrenia (non-DS) may support the DS/non-DS categorization of schizophrenia. For DS patients, non-DS patients, and for healthy controls, this study aims to evaluate the serum levels of: proinflammatory cytokines of interleukin (IL) 1β, tumor necrosis factor (TNF) α, Interferon (IFN) γ, IL-12, and IL-17; anti-inflammatory cytokines of IL-10, IFN-α, and transforming growth factor (TGF) β; and antioxidant biomarkers of paraoxonase1 (PON1) and Total Antioxidant Capacity (TAOC). Method Serum IL-1β, TNF-α, IFN-γ, IL-12, IL-17, IL-10, IFN-α, TGF-β, PON1 and TAOC levels were measured and performed in DS (n=26), non-DS (n=28), and healthy control (n=28) groups. Results Patients in the DS group had higher IL-17 levels than the non-DS group did. TGF-β values for both patient groups were significantly higher than those of the controls. PON1 and TAOC values for both patient groups were significantly lower than those of the controls. Conclusion Our findings may be evidence for the consideration that DS reflects a coherent entity within schizophrenia. Increased levels of IL-17 from pro-inflammatory cytokines may be related with DS. |
| Databáze: | OpenAIRE |
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