Interleukin‐12B gene rs6887695 and rs2288831 polymorphisms are associated with an increased risk of ulcerative colitis development in Chinese Han population: A case‐control study
| Autor: | Hai‐Hua Qian, Hui Zhao, Yun‐Zhi Qian |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male 0301 basic medicine Microbiology (medical) China rs2288831 rs6887695 Clinical Biochemistry Polymorphism Single Nucleotide Lesion 03 medical and health sciences 0302 clinical medicine Chinese han population Risk Factors medicine Humans Immunology and Allergy Genetic Predisposition to Disease Gene Genotyping Research Articles ulcerative colitis Interleukin-12 Subunit p40 business.industry Biochemistry (medical) Public Health Environmental and Occupational Health Case-control study Interleukin Hematology Middle Aged medicine.disease Ulcerative colitis Medical Laboratory Technology 030104 developmental biology Increased risk Case-Control Studies 030220 oncology & carcinogenesis IL‐12B Immunology Colitis Ulcerative Female medicine.symptom business Research Article |
| Zdroj: | Journal of Clinical Laboratory Analysis |
| ISSN: | 1098-2825 0887-8013 |
| Popis: | Background The association of the interleukin (IL)‐12B gene rs6887695 and rs2288831 polymorphisms with ulcerative colitis (UC) risk has been extensively investigated, but results are conflicting. In this study, we investigated potential link between the IL‐12B gene rs6887695 and rs2288831 polymorphisms and UC development in Chinese Han population. Material and Methods Genotyping was performed in 367 patients and 456 controls through polymerase chain reaction‐restriction fragment length polymorphism analysis. Plasma levels of IL‐12B were tested using an enzyme‐linked immunosorbent assay. Results We found that the IL‐12B gene rs6887695 and rs2288831 polymorphisms were related to a significantly increased risk of UC. Subgroup analyses revealed significant associations of the IL‐12B gene rs6887695 and rs2288831 polymorphisms with UC risk among females, consumers of alcohol, and those aged The IL‐12B gene rs6887695 and rs2288831 polymorphisms were related to a significantly increased risk of UC. The IL‐12B gene rs6887695 and rs2288831 polymorphisms were associated with IL‐12B levels. The rs6887695 and rs2288831 polymorphisms were associated with lesion location and UC treatment. |
| Databáze: | OpenAIRE |
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