Fatal bleeding due to a heparin-like anticoagulant in a 37-year-old woman suffering from systemic mastocytosis
| Autor: | M Stockschläder, Norbert Gattermann, Rüdiger E. Scharf, Christoph Sucker, Georg Mansmann, Stefan Steiner, Robert Loncar, Anette Schmitt-Graeff |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Adult
Pediatrics medicine.medical_specialty medicine.drug_class Heparin like medicine.medical_treatment Hemorrhage Fatal Outcome Mastocytosis Systemic Bone Marrow Female patient medicine Humans Mast Cells Systemic mastocytosis Chemotherapy business.industry Heparin Anticoagulant Anticoagulants Hematology General Medicine medicine.disease Pathophysiology Surgery Etiology Female Abnormality business |
| Zdroj: | Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis. 14(3) |
| ISSN: | 1076-0296 |
| Popis: | A 37-year-old female patient with systemic mastocytosis who was admitted with severe unexplained bleeding symptoms is studied. Laboratory procedures established the diagnosis of a patient-derived—heparin-like anticoagulant as a very rare hemostatic abnormality predisposing to bleeding. The patient died from refractory disease despite therapy with protamine, initiation of chemotherapy, and supportive measures. The case illustrates the clinical presentation and diagnosis of heparin-like anticoagulants. Etiology, pathophysiology, and therapeutic options are discussed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|