Heart failure with preserved ejection fraction, atrial fibrillation, and the role of senile amyloidosis
| Autor: | Bart A. Mulder, Bouke P. C. Hazenberg, Maarten P. van den Berg, Michiel Rienstra, Hans L A Nienhuis, Peter van der Meer, Dirk J. van Veldhuisen, Sebastiaan H C Klaassen, Alexander H. Maass |
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| Rok vydání: | 2018 |
| Předmět: |
INVOLVEMENT
Male medicine.medical_specialty Clinical Review Cardiomyopathy 030204 cardiovascular system & hematology FREQUENCY Transthyretin 03 medical and health sciences 0302 clinical medicine ENHANCEMENT Internal medicine MAGNETIC-RESONANCE Medicine Humans In patient Isolated atrial amyloidosis Heart Atria DEPOSITION Aged TRANSTHYRETIN CARDIAC AMYLOIDOSIS Heart Failure Frontiers in Cardiovascular Medicine Amyloid Neuropathies Familial CARDIOMYOPATHY biology business.industry Amyloidosis Atrial fibrillation Stroke Volume 030229 sport sciences Middle Aged medicine.disease HFpEF PREVALENCE biology.protein Cardiology Female Senile amyloidosis WILD-TYPE TRANSTHYRETIN SCINTIGRAPHY Cardiology and Cardiovascular Medicine business Heart failure with preserved ejection fraction |
| Zdroj: | European Heart Journal |
| ISSN: | 1522-9645 |
| Popis: | Heart failure with preserved ejection fraction (HFpEF) and atrial fibrillation (AF) are very common conditions, particularly in the elderly. However, the mechanisms underlying the two disorders, including their intricate interaction have not been fully resolved. Here, our aim is to review the evidence on the role of the two types of senile amyloidosis in this connection. Two types of senile amyloidosis can be identified: wild-type transthyretin (TTR)-derived amyloidosis (ATTRwt) and isolated atrial amyloidosis (IAA). ATTRwt is an underlying condition that is being increasingly recognized in patients with HFpEF and often accompanied by AF. IAA is an established cause of AF, adding to the mechanism problem. New diagnostic and therapeutic possibilities have emerged that may facilitate clinical management of (senile) amyloidosis, which in turn may have implications for the management of HFpEF and AF. |
| Databáze: | OpenAIRE |
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