From genetics to systems biology of stress-related mental disorders
| Autor: | Lee Lancashire, Nikolaos P. Daskalakis, Shareefa Dalvie, Foivos Georgiadis, Chris Chatzinakos, Obada Al Zoubi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Traumatic
Epigenomics Neurophysiology and neuropsychology Physiology Systems biology Neurosciences. Biological psychiatry. Neuropsychiatry Biochemistry Cellular and Molecular Neuroscience Endocrinology Stress (linguistics) medicine Genetics Original Research Article RC346-429 Molecular Biology Depression (differential diagnoses) Genetic association Endocrine and Autonomic Systems QP351-495 Traumatic stress medicine.disease Stress disorders Major depressive disorder Anxiety Neurology. Diseases of the nervous system medicine.symptom Psychology Transcriptome RC321-571 |
| Zdroj: | Neurobiology of Stress, Vol 15, Iss, Pp 100393-(2021) Neurobiology of Stress |
| ISSN: | 2352-2895 |
| Popis: | Many individuals will be exposed to some form of traumatic stress in their lifetime which, in turn, increases the likelihood of developing stress-related disorders such as post-traumatic stress disorder (PTSD), major depressive disorder (MDD) and anxiety disorders (ANX). The development of these disorders is also influenced by genetics and have heritability estimates ranging between ∼30 and 70%. In this review, we provide an overview of the findings of genome-wide association studies for PTSD, depression and ANX, and we observe a clear genetic overlap between these three diagnostic categories. We go on to highlight the results from transcriptomic and epigenomic studies, and, given the multifactorial nature of stress-related disorders, we provide an overview of the gene-environment studies that have been conducted to date. Finally, we discuss systems biology approaches that are now seeing wider utility in determining a more holistic view of these complex disorders. |
| Databáze: | OpenAIRE |
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