Clinical correlations and prognostic relevance of HGF, VEGF AND FGF expression in Brazilian patients with non-Hodgkin lymphoma

Autor:	Maria Aparecida Dalboni, Leina Yukari Etto, Otavio C. G. Baiocchi, Emílio C. A. Lacerda, André Luiz Vettore, Antonio Correa Alves, Vanderleia Costa Silva, Gisele W. B. Colleoni, Maria Célia Leme da Silva
Rok vydání:	2008
Předmět:	Adult Male Vascular Endothelial Growth Factor A Cancer Research medicine.medical_specialty Adolescent Angiogenesis medicine.medical_treatment Cell CD34 Severity of Illness Index Gastroenterology International Prognostic Index hemic and lymphatic diseases Internal medicine Severity of illness medicine Humans Aged Aged 80 and over Hepatocyte Growth Factor business.industry Lymphoma Non-Hodgkin Case-control study Hematology Middle Aged Prognosis medicine.disease Tumor Burden Lymphoma Fibroblast Growth Factors Cytokine Endocrinology medicine.anatomical_structure Oncology Case-Control Studies Cytokines Female business Brazil
Zdroj:	Leukemia & Lymphoma. 49:257-264
ISSN:	1029-2403 1042-8194
Popis:	The aims of this study were to correlate HGF, VEGF and FGF serum levels and microvessel density (MVD) with cell origin, biological behavior, tumor load and prognosis in NHL. Eighty-seven consecutive previously untreated NHL patients had serum samples collected; 37 (42%) of them also had serum follow-up samples; the control group was composed of 10 healthy blood donors. Cytokine serum levels were determined by ELISA, and MVD was measured by CD34 staining in paraffin blocks. HGF mean serum level was significantly higher in both early and advanced NHL stages when compared with the control group. HGF was also significantly higher in aggressive and indolent NHL when compared with the control group. Also, mean serum level of HGF in aggressive NHL was significantly higher than in indolent NHL. Regarding International Prognostic Index (IPI), HGF mean serum level at diagnosis was significantly higher for patients with IPI >2 when compared to IPI
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daa8adbfa1c774120d5304097b4a8dc8 https://doi.org/10.1080/10428190701769640 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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