MIG-13 controls anteroposterior cell migration by interacting with UNC-71/ADM-1 and SRC-1 inCaenorhabditis elegans
| Autor: | Takashi Hirose, Hiroki Moribe, Masato Okada, Kuniaki Nakamura, Nozomu Takata, Bunsho Itoh, Hitomi Masuda, Eisuke Mekada |
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| Rok vydání: | 2012 |
| Předmět: |
Mutant
Biophysics medicine.disease_cause Biochemistry Cell Movement Structural Biology Genetics medicine Animals Caenorhabditis elegans Caenorhabditis elegans Proteins Molecular Biology Suppressor mutation Neurons Mutation biology fungi Q neuroblast ADAM Membrane Proteins Metalloendopeptidases Cell migration Cell Biology biology.organism_classification Transmembrane protein MIG-13 Cell biology Phenotype Neural development nervous system RNA Interference Protein Kinases Src Signal Transduction Proto-oncogene tyrosine-protein kinase Src |
| Zdroj: | FEBS Letters. 586:740-746 |
| ISSN: | 0014-5793 |
| DOI: | 10.1016/j.febslet.2012.01.031 |
| Popis: | The transmembrane protein MIG-13 is a key regulator required for anterior migration of neural cells in Caenorhabditis elegans, but the signaling mechanisms involved remain unknown. Here, we isolated a suppressor mutation in the unc-71/adm-1 gene, which rescued the AVM neuron migration defect in mig-13 mutants. Genetic analyses revealed that UNC-71 at least partly acts downstream of MIG-13 and has an inhibitory effect on the anterior cell migration. The unc-71 mutation also rescued the anterior migration defect of AVM neuron in src-1 mutants. These findings suggest that MIG-13 controls anteroposterior cell migration by interacting with UNC-71 and SRC-1 in C. elegans. |
| Databáze: | OpenAIRE |
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