Interaction between Helicobacter pylori and host genetic variants in gastric carcinogenesis
| Autor: | Song-Ling Zhang, Bao-Sen Zhou, Xueyuan Cao, Zhifang Jia, Jing Jiang |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Cancer Research DNA Repair DNA damage Carcinogenesis Inflammation Helicobacter Infections 03 medical and health sciences 0302 clinical medicine Stomach Neoplasms medicine Humans Gastric carcinogenesis Gene Carcinogen Genetics Polymorphism Genetic biology Helicobacter pylori business.industry Genetic variants Genetic Variation General Medicine Methylation DNA Methylation bacterial infections and mycoses biology.organism_classification Gene Expression Regulation Neoplastic 030104 developmental biology Oncology 030220 oncology & carcinogenesis Host-Pathogen Interactions Cancer research Disease Susceptibility medicine.symptom business Biomarkers |
| Zdroj: | Future oncology (London, England). 12(18) |
| ISSN: | 1744-8301 |
| Popis: | Helicobacter pylori (H. pylori) is the definite carcinogen of gastric cancer. H. pylori infection induces chronic inflammation, causes DNA damage and aberrant methylation of genes and these pathways are involved in H. pylori-related gastric carcinogenesis. Polymorphisms of the genes involved in these pathways could alter susceptibility to gastric cancer. In this mini review, we focused on the role of polymorphisms in these genes on the susceptibility to gastric cancer, with a particular emphasis on their possible interactions with H. pylori infection. We found that many studies on this theme did not simultaneously report H. pylori infection and the interactions remained inconclusive. |
| Databáze: | OpenAIRE |
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