Effects of novel quinoid thiosulfonate derivative on ADP-induced platelet aggregation
| Autor: | Sviatoslav Polovkovych, Khrystyna Bolibrukh, Olexiy Savchuk, T. I. Halenova, I. Nikolaieva, Volodymyr Novikov |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
chemistry.chemical_compound
Screening test lcsh:Biology (General) Chemistry Stereochemistry Platelet-rich plasma Induced platelet aggregation platelet rich plasma quinoid thiosulfonate derivative ADP-induced platelet aggregation antiplatelet agents General Medicine Inhibitory effect lcsh:QH301-705.5 Derivative (chemistry) Quinone |
| Zdroj: | Vìsnik: Kiïvsʹkij Nacìonalʹnij Unìversitet Imenì Tarasa Ševčenka. Bìologìâ, Vol 68, Iss 3, Pp 36-40 (2016) |
| ISSN: | 2308-8036 1728-2748 |
| Popis: | Recently, in a large scale screening test, we have found that S-((1,4-dimethoxy-9,10-dioxo-9,10-dihydroanthracen-2-yl)methyl)4-aminobenzenesulfonothioate, a chemically synthesized thiosulfonate derivative of quinone, possessed an antiplatelet activity. To elucidate the mechanism of its antiplatelet action, a series of experiments were performed. The compound was found to inhibit the ADP-induced platelet aggregation. The inhibitory effect was dose-dependent on concentration and preincubation time. The derivative also disaggregated the preformed platelet aggregates induced by ADP. |
| Databáze: | OpenAIRE |
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