Mild gentamicin nephrotoxicity reduces the progression of chronic adriamycin nephrosis
| Autor: | Gopala K. Rangan, Liguang Chen, David Harris, Yuet-Ching Tay, Yiping Wang |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
medicine.medical_specialty
Creatinine Proteinuria business.industry medicine.medical_treatment Intraperitoneal injection Glomerulosclerosis Renal function General Medicine medicine.disease Nephrotoxicity chemistry.chemical_compound Endocrinology chemistry Nephrology Internal medicine medicine Gentamicin medicine.symptom business Saline medicine.drug |
| Zdroj: | Nephrology. 4:57-64 |
| ISSN: | 1320-5358 |
| DOI: | 10.1111/j.1440-1797.1998.tb00322.x |
| Popis: | SUMMARY: The effect of mild acute tubular injury on the progression of tubulointerstitial fibrosis was studied in pair-fed uninephrectomized male Wistar rats with established adriamycin nephrosis (n= 34). Rats were stratified into three groups according to endogenous creatinine clearance (CrCl), proteinuria (Upr) and body weight (BW): (i) group 1 (Fe, n= 12) received a single intraperitoneal injection of ferric nitrilotriacetate (5 mg Fe/kg BW); (ii) group 2 (G, n= 10) three daily subcutaneous injections of gentamicin (60 mg/kg BW) and; (iii) group 3 (C, n= 12) saline injections. Serial CrCl (day 2, day 5, weeks 2, 4, 6 and 8) and renal histology (week 8) were examined following administration of nephrotoxin. CrCl was reduced on d2 (Fe: 0.78 ± 0.23 mL/min; mean ± SD) and day 5 (G: 0.91 ± 0.36 mL/min) as compared with C (1.22 ± 0.12 mL/min; P |
| Databáze: | OpenAIRE |
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