Neurosarcoidosis Presenting as Aseptic Meningitis in an Immunosuppressed Renal Transplant Recipient
| Autor: | Edward D. Siew, Wendell Lake, Elizabeth P. Held, Edward A. Iglesia, Ty W. Abel, John Y. Fang, Matthew H. Wilson, Adam S. Johnson |
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| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_specialty Sarcoidosis medicine.medical_treatment Peptidyl-Dipeptidase A Organ transplantation Immunocompromised Host 03 medical and health sciences 0302 clinical medicine Central Nervous System Diseases Activities of Daily Living medicine Humans Meningitis Aseptic 030212 general & internal medicine Kidney transplantation Autoimmune disease Transplantation medicine.diagnostic_test business.industry Brain biopsy Neurosarcoidosis Aseptic meningitis Immunosuppression Middle Aged medicine.disease Kidney Transplantation Dermatology business 030217 neurology & neurosurgery |
| Zdroj: | Transplantation. 100:e96-e100 |
| ISSN: | 0041-1337 |
| Popis: | BACKGROUND Sarcoidosis is a presumptive autoimmune disorder characterized by the presence of noncaseating granulomas and is usually treated successfully with immunosuppression. METHODS AND RESULTS Here, we describe the case of a 63-year-old male renal transplant recipient with a remote history of pulmonary sarcoidosis on chronic immunosuppression who developed recurrent aseptic meningitis and underwent brain biopsy revealing a diagnosis of neurosarcoidosis. CONCLUSIONS This case highlights the possibility of recurrence of sarcoidosis in the setting of maintenance immunosuppression, the need for heightened awareness of alternative sites of recurrence of autoimmune disease, and future studies to determine the underlying mechanism of recurrence in organ transplant recipients. |
| Databáze: | OpenAIRE |
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