Mutagenicity of 4,4'-methylenedianiline derivatives in the Salmonella histidine reversion assay
| Autor: | B. E. Allen, T.K. Rao, G. F. Dorsey, J. L. Epler |
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| Rok vydání: | 1982 |
| Předmět: |
Male
endocrine system Salmonella 4 4'-Methylenedianiline Health Toxicology and Mutagenesis Reversion In Vitro Techniques Toxicology medicine.disease_cause Frameshift mutation chemistry.chemical_compound Structure-Activity Relationship medicine Animals Histidine Aniline Compounds Chemistry Mutagenicity Tests fungi Mutagenesis food and beverages Rats Inbred Strains General Medicine Rats Biochemistry Microsome Microsomes Liver Phenobarbital medicine.drug Mutagens |
| Zdroj: | Archives of toxicology. 49(3-4) |
| ISSN: | 0340-5761 |
| Popis: | 4,4′-Methylenedianiline and its derivatives were assayed for mutagenicity in the Salmonella/microsomal mutagenicity assay developed by Ames. A specificity to revert strain TA98 suggests a mechanism of frameshift mutagenesis. Liver microsomal preparations (S-9) from rats induced with phenobarbital were most effective for metabolic activation. Alkyl substitution of 4,4′-methylenedianiline did not alter its mutagenic activity; however, substitution of both positions ortho to the amino group eliminated mutagenic activity. Substitution with alkoxy-carbonyl groups eliminated mutagenic activity, whereas halogen substitution (chlorine, fluorine) enhanced the mutagenic activity. The results presented here show the use of structure-activity studies as predictive tools for the assessment of genotoxic properties of industrial chemicals. |
| Databáze: | OpenAIRE |
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