Absence of the transcription factorNfibdelays the formation of the basilar pontine and other mossy fiber nuclei
| Autor: | Richard M. Gronostajski, Asli Kumbasar, Celine Plachez, E. David Litwack, Linda J. Richards |
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| Rok vydání: | 2009 |
| Předmět: |
Nervous system
PAX6 Transcription Factor Population Hindbrain Biology Cerebellar Cortex Mice Pons Neural Pathways medicine Animals Paired Box Transcription Factors Mossy fiber (cerebellum) Eye Proteins education Rhombic lip Homeodomain Proteins Mice Knockout Neurons education.field_of_study Nuclear factor I General Neuroscience Neurogenesis Pontine nuclei Mice Inbred C57BL Repressor Proteins Rhombencephalon NFI Transcription Factors Phenotype medicine.anatomical_structure nervous system Neuroscience |
| Zdroj: | The Journal of Comparative Neurology. 513:98-112 |
| ISSN: | 1096-9861 0021-9967 |
| DOI: | 10.1002/cne.21943 |
| Popis: | Transcription factors of the Nuclear Factor I (Nfi) family are important for the development of specific neuronal and glial populations in the nervous system. One such population, the neurons of the basilar pontine nuclei, expresses high levels ofNfiproteins, and the pontine nuclei are greatly reduced in mice lacking a functionalNfibgene. Pontine neurons, along with other precerebellar neurons that populate the hindbrain, arise from precursors in the lower rhombic lip and migrate anteroventrally to reach their final location. Using immunohistochemistry, we find that NFI-B expression is specific for mossy fiber populations of the precerebellar system. Analysis of theNfib !/! hindbrain in dicates that the development of the basilar pontine nuclei is delayed, with pontine neurons migrating 1‐2 days later than in control animals, and that significantly fewer pontine neurons are produced. While the mossy fiber nuclei of the caudal medulla do form, they also exhibit a developmental delay.NfiaandNfixnull mice exhibit no apparent pontine phenotype, implying specificity in the action of NFI family members. Collectively, these data demonstrate thatNfib plays an important role in the generation of precerebellar mossy fiber neurons, and may do so at least in part by regulating neurogenesis. J. Comp. Neurol. 513:98‐112 |
| Databáze: | OpenAIRE |
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