Impacts of survivin and caspase-3 on apoptosis and angiogenesis in oral cancer
| Autor: | Yanqi Yang, Zheng Sun, Xiao-fei Tang, Yan-ping Ding, Shuxia Li |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Cancer Research Epithelial dysplasia Oncogene Angiogenesis Cancer Articles Biology medicine.disease Malignant transformation 03 medical and health sciences stomatognathic diseases 030104 developmental biology 0302 clinical medicine Oncology Terminal deoxynucleotidyl transferase 030220 oncology & carcinogenesis Survivin Cancer research medicine Immunohistochemistry |
| Popis: | The present study aimed to investigate the impact of survivin and caspase-3 on apoptosis and angiogenesis in oral cancer. A total of 16 oral leukoplakia cases accompanied by low-moderate epithelial dysplasia, 12 cases of oral leukoplakia accompanied by severe epithelial dysplasia, 17 cases of high-moderate differentiated oral squamous cell carcinoma and 10 cases of normal oral mucosa were selected. Immunohistochemistry was used to detect the expression levels of survivin, caspase-3, and caspase inhibitor factor VIII in lesions from each group. Terminal deoxynucleotidyl transferase 2'-deoxyuridine, 5'-triphosphate nick end labeling was performed to detect the apoptotic index of oral leukoplakia and cancer tissue. Immunohistochemistry revealed increased expression levels of survivin in oral cancer tissues, as compared with the normal mucosa, whereas the expression of Caspase-3 was decreased during malignant transformation. Microvascular density (MVD) was increased from 28.49±11.87 strips/mm2 (mean ± standard deviation, normal control group) to 91.98±40.20 strips/mm2 (oral cancer group). Therefore, survivin may serve an important role in oral cancer, as its expression was increased in association with a downward trend in caspase-3 expression and apoptotic index, whereas MVD was significantly increased. |
| Databáze: | OpenAIRE |
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