Gut microbiota: effect of pubertal status

Autor:	Xin Yuan, Xiaohong Yang, Xiangquan Lin, Ying Zhang, Ruimin Chen
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	Microbiology (medical) Male Adolescent medicine.drug_class Firmicutes lcsh:QR1-502 Physiology Gut microbiota Gut flora Microbiology digestive system lcsh:Microbiology 03 medical and health sciences 0302 clinical medicine RNA Ribosomal 16S medicine Humans Testosterone Child Children 030304 developmental biology 0303 health sciences biology Bacteria Ruminococcus Puberty Bacteroidetes biology.organism_classification Parabacteroides Androgen Gastrointestinal Microbiome Cross-Sectional Studies Child Preschool Female 16 s rRNA Proteobacteria 030217 neurology & neurosurgery Research Article
Zdroj:	BMC Microbiology, Vol 20, Iss 1, Pp 1-9 (2020) BMC Microbiology
ISSN:	1471-2180
Popis:	Background The make-up of gut microbiota at different puberty stages has not been reported. This cross-sectional study analyzed the bio-diversity of gut microbiota at different puberty stages. Result The subjects (aged 5–15 years) were divided into non-pubertal (n = 42, male%: 66.7%) or pubertal groups (n = 47, male%:44.68); in both groups, Firmicutes, Bacteroidetes and Proteobacteria were the dominant phylum. There was no difference of alpha- and beta-diversity among disparate puberty stages. Non-pubertal subjects had members of the order Clostridiales, family Clostridiaceae, genus Coprobacillus which were significantly more prevalent than puberty subjects. Also, the pubertal subjects had members of class Betaproteobacteria, order Burkholderiales which were significantly more prevalent than the non-pubertal subjects. Their relative abundance was independent of BMI-Z. In the pubertal subjects, the abundance of genus Adlercreutzia, Ruminococcus, Dorea, Clostridium and Parabacteroides was associated with the level of testosterone. Conclusions This is the first report of the diversity of gut microbiota at different puberty stages. The various species of gut microbiota changed gradually associated with puberty stages. Differences in gut microflora at different pubertal status may be related to androgen levels.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da92b16eddfcbde38086e0f0a08f4910 http://link.springer.com/article/10.1186/s12866-020-02021-0 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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