Combination of thermal and cavitation effects to generate deep lesions with an endocavitary applicator using a plane transducer: ex vivo studies
| Autor: | David Melodelima, Y. Theillere, Dominique Cathignol, Jean-Yves Chapelon |
|---|---|
| Přispěvatelé: | Applications des ultrasons à la thérapie, Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM) |
| Rok vydání: | 2004 |
| Předmět: |
Hot Temperature
Materials science Acoustics and Ultrasonics Swine Ultrasonic Therapy Transducers Biophysics MESH: Heat Rotation 01 natural sciences Temperature measurement 030218 nuclear medicine & medical imaging thermal ablation Necrosis 03 medical and health sciences 0302 clinical medicine Optics cavitation high intensity ultrasound Ultrasound 0103 physical sciences Animals MESH: Animals Radiology Nuclear Medicine and imaging MESH: Swine 010301 acoustics MESH: Necrosis Radiological and Ultrasound Technology business.industry Plane (geometry) Acoustics Equipment Design MESH: Electronics Medical MESH: Ultrasonic Therapy Sound intensity Electronics Medical Transducer Liver plane transducer MESH: Acoustics Cavitation Attenuation coefficient endocavitary [SDV.IB]Life Sciences [q-bio]/Bioengineering business MESH: Equipment Design MESH: Liver MESH: Transducers |
| Zdroj: | Ultrasound in Medicine & Biology Ultrasound in Medicine & Biology, Elsevier, 2004, 30 (1), pp.103-11. ⟨10.1016/j.ultrasmedbio.2003.09.005⟩ |
| ISSN: | 0301-5629 |
| DOI: | 10.1016/j.ultrasmedbio.2003.09.005 |
| Popis: | International audience; In the high-intensity focused ultrasound (US), or HIFU, field, it is well-known that the cavitation effect can be used to induce lesions of larger volume. The principle is based on the increase in the equivalent attenuation coefficient of the tissue in the presence of the bubbles created by cavitation. The elementary lesions produced by combination of cavitation and thermal effects, using focused transducers, were spherical and developed upstream of the focal point. This paper presents a method that combines cavitation with a thermal effect to obtain deeper lesions using a plane transducer, rather than a focused one. The cavitation effect was produced by delivering intensities of 60 W/cm2 at the face of the transducer for 0.5 s. The applicator was then rotated through 90 degrees at a constant speed of between 0.5 and 1.5 degrees /s. During this rotation, ex vivo tissues were exposed continuously to an acoustic intensity of 14 W/cm2 to combine the cavitation effect with a thermal effect. The necroses were, on average, twice as deep when the cavitation effect was used as those obtained with a thermal effect alone. Observed macroscopically, the lesions have a very well-delimited geometry. Temperature measurements made at different angles of treatment have shown that they were coagulation necroses. |
| Databáze: | OpenAIRE |
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