Pentosidine in chronic hemodialysis patients: relation with arteriovenous fistula morphology and function

Autor: Diana Moldovan, Cosmina Ioana Bondor, Livia Budisan, Ina Maria Kacso, Maria Ticala, Dacian Tirinescu, Anca Laura Coman, Alina Potra, Crina Rusu
Rok vydání: 2019
Předmět:
Zdroj: International Urology and Nephrology. 51:1035-1042
ISSN: 1573-2584
0301-1623
DOI: 10.1007/s11255-019-02151-z
Popis: It has been suggested that advanced glycation end products (AGEs) are involved in atherogenesis, vascular calcification and remodeling, including neointimal hyperplasia, in renal and non-renal patients. Their relevance for arteriovenous fistula (AVF) function has been poorly studied to date, with only one clinical study addressing the issue of thrombosis of vascular access in relation to AGEs in dialysis patients. We aimed to evaluate the relationship between serum pentosidine and AVF morphology and function. Eighty-eighth hemodialysis patients with patent native AVF were included. Ultrasound examination of AVF evaluated blood flow in the brachial artery, resistivity index (RI), the diameter of the vessels and the presence of stenosis. AVF and cardiovascular history were recorded, routine clinical and laboratory evaluation was performed and serum pentosidine was assessed. Forty-eight patients (54.54%) had AVF stenosis. Pentosidine correlated in univariate analysis with cholesterol (r = 0.270, p = 0.01), triglycerides (r = 0.309, p = 0.003), calcium (r = 0.040, p
Databáze: OpenAIRE
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