[18F]fluoride from a small cyclotron for the routine synthesis of [18F]2-fluoro-2-deoxy-D-glucose
| Autor: | S. J. Gatley, Onofre T. DeJesus, J. A. Martin, M. D. Cooper, N. J. Yasillo |
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| Rok vydání: | 1986 |
| Předmět: |
Blood Glucose
Radioisotopes 18f 2 fluoro 2 deoxy d glucose Cyclotron General Engineering Fluorine Deoxyglucose law.invention Low volume chemistry.chemical_compound chemistry law Fluorodeoxyglucose F18 Deoxy Sugars Humans Particle Accelerators 18f fluoride Fluoride Derivative (chemistry) Nuclear chemistry Production rate Tomography Emission-Computed |
| Zdroj: | International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes. 37(5) |
| ISSN: | 0883-2889 |
| Popis: | [ 18 F]Fluoride was produced via the 18 O (p, n) 18 F reaction using a low volume stainless steel 18 O-water target in a small cyclotron. The average 18 F production rate for 60 runs was about 720 μCi/μA-min. A typical bombardment time of 20 min produced 120 mCi of 18 F-fluoride. [ 18 F]2-Fluoro-2-deoxy- d -glucose ([ 18 F]2FDG) was prepared using the procedure developed by Tewson [ J. Nucl. Med. 24 , 718 (1983)] involving a protected cyclic sulfate glucose derivative as precursor. The routine synthesis and quality testing of [ 18 F]2FDG required 1 h and, typically, yields of 30–35 mCi of > 95% HPLC-pure product were obtained. |
| Databáze: | OpenAIRE |
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