Intestinal mucus barrier: a missing piece of the puzzle in food allergy
| Autor: | Markus Ollert, Mahesh Desai, Marie Boudaud, Amy Parrish, Annette Kuehn |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Allergy
gastrointestinal mucus layer gut microbiome allergic sensitization Context (language use) mucin-degrading bacteria Allergic sensitization Immune system Food allergy Medicine Humans mucosal immune system Microbiome Intestinal Mucosa Molecular Biology food allergy Intestinal mucus Bacteria business.industry digestive oral and skin physiology medicine.disease Mucus Gastrointestinal Microbiome Immunology Molecular Medicine business Food Hypersensitivity |
| Zdroj: | Parrish, A, Boudaud, M, Kuehn, A, Ollert, M & Desai, M S 2022, ' Intestinal mucus barrier : a missing piece of the puzzle in food allergy ', Trends in Molecular Medicine, vol. 28, no. 1, pp. 36-50 . https://doi.org/10.1016/j.molmed.2021.10.004 |
| ISSN: | 1471-499X |
| DOI: | 10.1016/j.molmed.2021.10.004 |
| Popis: | The prevalence of food allergies has reached epidemic levels but the cause remains largely unknown. We discuss the clinical relevance of the gut mucosal barrier as a site for allergic sensitization to food. In this context, we focus on an important but overlooked part of the mucosal barrier in pathogenesis, the glycoprotein-rich mucus layer, and call attention to both beneficial and detrimental aspects of mucus–gut microbiome interactions. Studying the intricate links between the mucus barrier, the associated bacteria, and the mucosal immune system may advance our understanding of the mechanisms and inform prevention and treatment strategies in food allergy. |
| Databáze: | OpenAIRE |
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