In Vivo Cell Tracking Using PET: Opportunities and Challenges for Clinical Translation in Oncology
| Autor: | Ferdia A. Gallagher, Bala Attili, Luigi Aloj, Laura M. Lechermann, Doreen Lau |
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| Přispěvatelé: | Lechermann, Laura M. [0000-0002-2742-6269], Lau, Doreen [0000-0002-7623-2401], Aloj, Luigi [0000-0002-7452-4961], Gallagher, Ferdia A. [0000-0003-4784-5230], Apollo - University of Cambridge Repository, Lechermann, Laura M [0000-0002-2742-6269], Gallagher, Ferdia A [0000-0003-4784-5230] |
| Rok vydání: | 2021 |
| Předmět: |
Cancer Research
PET/CT medicine.medical_treatment Cell Review Cell therapy In vivo direct cell labelling Medicine RC254-282 PET-CT medicine.diagnostic_test business.industry Neoplasms. Tumors. Oncology. Including cancer and carcinogens Immunotherapy medicine.anatomical_structure PET/MRI Oncology cell tracking Positron emission tomography immuno-PET Cancer research immunotherapy cell therapy reporter genes business Preclinical imaging Ex vivo |
| Zdroj: | Cancers, Vol 13, Iss 4042, p 4042 (2021) Cancers |
| Popis: | Simple Summary Tracking therapeutic cells with non-invasive imaging methods has the potential to provide important information on the efficacy of cell therapies. In oncology, for example, monitoring the spatial distribution of chimeric antigen receptor (CAR) T-cells or tumour-infiltrating lymphocytes (TILs) could be used to monitor the efficiency of cellular trafficking to target sites within a patient. This review covers different cell labelling approaches for the non-invasive detection of therapeutic cells using positron emission tomography (PET). The potential for the clinical translation of these approaches and first-in-human studies is examined, as well as the translational challenges involved and how imaging can help overcome some of these challenges. Abstract Cell therapy is a rapidly evolving field involving a wide spectrum of therapeutic cells for personalised medicine in cancer. In vivo imaging and tracking of cells can provide useful information for improving the accuracy, efficacy, and safety of cell therapies. This review focuses on radiopharmaceuticals for the non-invasive detection and tracking of therapeutic cells using positron emission tomography (PET). A range of approaches for imaging therapeutic cells is discussed: Direct ex vivo labelling of cells, in vivo indirect labelling of cells by utilising gene reporters, and detection of specific antigens expressed on the target cells using antibody-based radiopharmaceuticals (immuno-PET). This review examines the evaluation of PET imaging methods for therapeutic cell tracking in preclinical cancer models, their role in the translation into patients, first-in-human studies, as well as the translational challenges involved and how they can be overcome. |
| Databáze: | OpenAIRE |
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