The heat/capsaicin sensitization model: A methodologic study
| Autor: | Karin L. Petersen, J rgen B. Dahl, Jesper Dirks |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Adult
Male Hot Temperature Time Factors Adolescent Models Neurological Stimulation Pharmacology Random order chemistry.chemical_compound Reference Values Physical Stimulation medicine Humans Sensitization Pain Measurement Skin Cross-Over Studies Topical capsaicin business.industry Reproducibility of Results Crossover study Anesthesiology and Pain Medicine medicine.anatomical_structure Neurology chemistry Hyperalgesia Capsaicin Anesthesia Reference values lipids (amino acids peptides and proteins) Neurology (clinical) medicine.symptom business |
| Zdroj: | The Journal of Pain. 4:122-128 |
| ISSN: | 1526-5900 |
| DOI: | 10.1054/jpai.2003.10 |
| Popis: | The heat/capsaicin sensitization model induces cutaneous sensitization by using a combination of heat and topical capsaicin. It has been suggested that the stability and duration of the cutaneous sensitization are due to a synergistic effect between heat and capsaicin. The aim of this study was to evaluate a possible synergistic effect between heat and capsaicin in inducing cutaneous sensitization. Twenty healthy male volunteers completed this random order, 4-session study. Three different stimulation combinations were used to induce cutaneous sensitization: day A, heat and capsaicin; day B, heat alone; day C, capsaicin alone. Combination A was repeated on day D to determine between day reproducibility. Rekindling was performed 3 times at 40-minute intervals to maintain stable areas of secondary hyperalgesia. Brief thermal sensitization (45 degrees C for 3 minutes) was induced at each session. Within and between day reproducibility was calculated. There was no difference between the size of areas of secondary hyperalgesia after stimulation with heat/capsaicin compared to heat and capsaicin stimulation alone. The within day reproducibility was better with heat/capsaicin than with either stimulation alone. There was no synergistic or additive effect between heat and capsaicin in inducing cutaneous sensitization. Rekindling seems to be the important factor in maintaining stable and long-lasting cutaneous sensitization. |
| Databáze: | OpenAIRE |
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