Combined Low-Dose Acetylsalicylic Acid and Dihydroergotamine in Migraine Prophylaxis: A Double-Blind, Placebo-Controlled Crossover Study
| Autor: | Thierry Soisson, Eliane Fuseau, Jacques Chick, Marie-Germaine Bousser, Robert Thevenet |
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| Rok vydání: | 1988 |
| Předmět: |
Adult
Male Adolescent Migraine Disorders Placebo Dihydroergotamine Migraine prophylaxis Placebos Double blind Double-Blind Method medicine Humans Aged Aspirin Dose-Response Relationship Drug business.industry Low dose General Medicine Middle Aged medicine.disease Crossover study Drug Combinations Migraine Anesthesia Female Neurology (clinical) Active treatment business medicine.drug |
| Zdroj: | Cephalalgia. 8:187-192 |
| ISSN: | 1468-2982 0333-1024 |
| DOI: | 10.1046/j.1468-2982.1988.0803187.x |
| Popis: | The efficacy of the combination of dihydroergotamine (10 mg) with acetylsalicylic acid (80 mg) (DHE + ASA) in the prophylaxis of migraine was studied in a double-blind, placebo-controlled crossover trial (8 weeks twice). Of 45 patients who entered the study, 38 completed it. The number of attacks was significantly ( p = 0.003) reduced during active treatment (11.5 ± 6.2) compared with placebo (16.6 ± 9.9). The mean duration, the mean severity, and the mean score for symptomatic acute medication of attacks did not differ significantly. The overall assessment made by the patients themselves was in favor of DHE + ASA ( p = 0.001). These results indicate a moderately beneficial effect of the dihydroergotamine/low-dose acetylsalicylic acid combination in migraine prophylaxis. |
| Databáze: | OpenAIRE |
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