Inflammatory Demyelinating Central Nervous System Diseases in Childhood: Clinical and Paraclinical Profiles in 133 Patients
Autor: | Egemen Idiman, Derya Kaya, Serkan Ozakbas |
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Jazyk: | angličtina |
Rok vydání: | 2012 |
Předmět: |
lcsh:Immunologic diseases. Allergy
Pediatrics medicine.medical_specialty Neuromyelitis optica Clinically isolated syndrome Disease onset Article Subject business.industry Multiple sclerosis Medical record Immunology Central nervous system medicine.disease medicine.anatomical_structure Immunology and Microbiology (miscellaneous) medicine Immunology and Allergy Secondary progressive multiple sclerosis Demyelinating Disorder business lcsh:RC581-607 Research Article |
Zdroj: | Autoimmune Diseases Autoimmune Diseases, Vol 2012 (2012) |
ISSN: | 2090-0430 2090-0422 |
Popis: | In a retrospective review of patients with acquired demyelinating disorders of the central nervous system, 133 patients (5.6%) whose diseases started in childhood, were selected from 2369 patients, who had medical records in the Neurology Department of Dokuz Eylul University. Out of 133, 98 had relapsing remitting multiple sclerosis, 21 had secondary progressive multiple sclerosis, 8 had clinically isolated syndrome, 3 had neuromyelitis optica, 2 had Marburg disease, and 1 had radiologically isolated syndrome. In 55 patients (41.3%), disease onset was before age 16. Polysymptomatic presentation (22.6%) was the most common initial feature. The EDSS scores ranged from 0 to 9 with a median of 2.0 (2.22 ± 1.88) for 126 patients. MRI records of 111 patients were obtained. 97 patients had clinically definite multiple sclerosis. 11 MS patients (11.3%) did not initially present the diagnostic MRI features. All of the remaining multiple sclerosis patients fulfilled Barkhof-Tintore criteria (100%) and 88.7% fulfilled KIDMUS criteria. Cranial MRI of NMO patients was normal. Our findings demonstrate some important clinical and paraclinical features that can help the literature on acquired demyelinating disorders of childhood by utilizing data from Western Turkey. © 2012 Derya Kaya et al. |
Databáze: | OpenAIRE |
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