The mouse neurological mutant weaver maps within the region of chromosome 16 that is homologous to human chromosome 21
| Autor: | William J. Pavan, Michael R. Crowley, Roger H. Reeves, Dan Goldowitz, N. M. Lorenzon, Richard J. Smeyne |
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| Rok vydání: | 1989 |
| Předmět: |
Electrophoresis
Male Chromosomes Human Pair 21 Genetic Linkage Mutant Biology medicine.disease_cause Chromosomes Mice Mice Neurologic Mutants Chromosome 16 Sequence Homology Nucleic Acid Genetics medicine Homologous chromosome Animals Humans Alleles Crosses Genetic Recombination Genetic Chromosome 7 (human) Mutation Molecular biology Mice Inbred C57BL Chromosome 17 (human) Blotting Southern Female Chromosome 21 Chromosome 22 Polymorphism Restriction Fragment Length |
| Zdroj: | Genomics. 5:522-526 |
| ISSN: | 0888-7543 |
| DOI: | 10.1016/0888-7543(89)90018-9 |
| Popis: | Utilizing the backcross C57BL/6 wv/wv x (C57BL/6 wv/wv x MOLD/Rk), the mouse neurological mutation weaver (wv) was mapped less than 1 cM proximal to Ets-2 and Mx on mouse chromosome 16 (0.96 +/- 0.1% recombination). This region is known to include eight genes that are found on human chromosome 21 (HSA 21) and appears to be highly conserved between the two species. We therefore predict that the normal human homolog of wv will be located on HSA 21 and would be in dosage imbalance in individuals with Down syndrome. |
| Databáze: | OpenAIRE |
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