Molecular epidemiology and mapping of tuberculosis in Israel: do migrants transmit the disease to locals?
| Autor: | Zeev Dveyrin, Hasia Kaidar-Shwartz, Daniel Chemtob, Efrat Rorman, Drora Goldblatt, N. Cedar, P. J. Freidlin, Zohar Mor |
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| Rok vydání: | 2014 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty Time Factors Tuberculosis Genotype Emigrants and Immigrants Disease cluster law.invention Mycobacterium tuberculosis Predictive Value of Tests Risk Factors law Epidemiology medicine Cluster Analysis Humans Israel Bacteriological Techniques Molecular Epidemiology Molecular epidemiology biology Traditional medicine business.industry Emigration and Immigration medicine.disease biology.organism_classification Infectious Diseases Transmission (mechanics) Molecular Diagnostic Techniques Cohort Contact Tracing business geographic locations Contact tracing Demography |
| Zdroj: | The International Journal of Tuberculosis and Lung Disease. 18:1085-1091 |
| ISSN: | 1027-3719 2008-2010 |
| DOI: | 10.5588/ijtld.14.0186 |
| Popis: | SETTING Israel receives migrants from various countries, some of which have high tuberculosis (TB) prevalence. OBJECTIVE To assess the predominant Mycobacterium tuberculosis strains in Israel isolated during 2008-2010 among Israeli-born and migrant patients, and to investigate possible transmission of TB from migrants to the local population. METHODS Molecular characterisation employed 43-spacer spoligotyping and 16-loci mycobacterial interspersed repetitive units-variable number of tandem repeats typing. All patients were classified according to those who were members of a cluster and those who were not. RESULTS Among 684 M. tuberculosis strains isolated from new patients genotyped and assigned to their specific cohort populations during the study period, major spoligotype families were Central Asian (CAS) (n = 140, 20%), Beijing (n = 101, 15%) and T (n = 160, 23%). Most Beijing strains (66%) were isolated from patients from the former Soviet Union (FSU), while CAS strains were mainly (74%) from Ethiopia, Eritrea and Sudan (EES). For the heterogeneous T-clade, patient countries of origin were 38% EES and 33% FSU. CONCLUSIONS Predominant M. tuberculosis genotypes in Israel in 2008-2010 were similar to genotypes endemic to the migrants' countries of origin. Epidemiological investigations did not demonstrate transmission between migrants and Israeli-born patients sharing the same cluster. |
| Databáze: | OpenAIRE |
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