An insight into osteoarthritis susceptibility: Integration of immunological and genetic background
| Autor: | Dzihan Abazovic, Gordana Supic, Vladimir Vranic, Nemanja Ivkovic, Debora Stefik, Danilo Vojvodic, Dusan Maric |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Review Article Osteoarthritis Bioinformatics immunology Pathogenesis 03 medical and health sciences Joint disease 0302 clinical medicine Degenerative disease genetic polymorphisms Environmental risk medicine Genetic predisposition Humans Synovial joints lcsh:R5-920 business.industry General Medicine medicine.disease Pathophysiology 030104 developmental biology 030220 oncology & carcinogenesis lcsh:Medicine (General) business genetic susceptibility |
| Zdroj: | Bosnian Journal of Basic Medical Sciences Bosnian Journal of Basic Medical Sciences (2020) |
| ISSN: | 1840-4812 1512-8601 |
| Popis: | Osteoarthritis (OA) is a progressive degenerative disease that affects all synovial joints, causing the disability of the main locomotor diarthrodial joints. OA pathogenesis is caused by a complex interplay between a number of genetic and environmental risk factors, involved in the early onset and progression of this chronic inflammatory joint disease. Uncovering the underlying immunological and genetic mechanisms will enable an insight into OA pathophysiology and lead to novel and integrative approaches in the treatment of OA patients, together with a reduction of the disease risk, or a delay of its onset in susceptible patients. |
| Databáze: | OpenAIRE |
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