Nociceptin inhibits the neurogenic vasopressor response in the pithed rat via prejunctional ORL 1 receptors
| Autor: | Eberhard Schlicker, Hanna Kozłowska, B. Malinowska, B. Koneczny |
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| Rok vydání: | 2000 |
| Předmět: |
Male
Nicotine Autonomic Fibers Preganglionic Narcotic Antagonists Pharmacology toxicology Neuromuscular Junction Blood Pressure In Vitro Techniques Vagotomy Pharmacology Inhibitory postsynaptic potential Nociceptin Receptor Norepinephrine medicine Animals Nervous System Physiological Phenomena Nicotinic Agonists Rats Wistar Sympathomimetics Receptor Decerebrate State Naloxone Chemistry General Medicine Electric Stimulation Rats Nociceptin receptor Blood pressure Opioid Peptides Opioid Anesthesia Receptors Opioid Orphanin FQ medicine.drug |
| Zdroj: | Naunyn-Schmiedeberg's Archives of Pharmacology. 361:80-84 |
| ISSN: | 1432-1912 0028-1298 |
| DOI: | 10.1007/s002109900160 |
| Popis: | Nociceptin (or orphanin FQ), the endogenous ligand for the opioid receptor-like 1 (ORL1) receptor, decreases blood pressure in the conscious and anesthetized rat. This study examined whether prejunctional inhibitory ORL1 receptors located on the postganglionic sympathetic neurons innervating the resistance vessels are detectable in pithed rats. In pithed and vagotomized rats electrical stimulation of the preganglionic sympathetic nerve fibers, injection of nicotine (2 micromol/kg) or noradrenaline (1 nmol/kg) increased blood pressure by about 30 mmHg. The electrically induced vasopressor response was decreased dose-dependently by nociceptin (0.001-1 micromol/kg; decrease by about 60% at 1 micromol/kg). Nociceptin 0.1 micromol/kg reduced the nicotine-induced vasopressor response by about 40% but at doses up to 1 micromol/kg failed to affect the increase in blood pressure evoked by noradrenaline. The inhibitory action of nociceptin on the electrically and nicotine-induced increase in blood pressure was attenuated by the ORL1 receptor antagonists naloxone benzoylhydrazone (5 micromol/kg) and/or [Phe1psi(CH2-NH)Gly2]-nociceptin(1-13)NH2 (1 micromol/kg) but was not affected by naloxone 10 micromol/kg. In conclusion, the present data suggest that the postganglionic sympathetic nerve fibers innervating the resistance vessels of the rat are endowed with prejunctional ORL1 receptors, activation of which causes inhibition of noradrenaline release. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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