Subjective cognitive decline and self-reported sleep problems: The SCIENCe project

Autor: Lieza G. Exalto, Heleen M.A. Hendriksen, Frederik Barkhof, Karlijn A. van den Bosch, Jarith L. Ebenau, Mardou van Leeuwenstijn‐Koopman, Niels D. Prins, Charlotte E. Teunissen, Leonie N.C. Visser, Philip Scheltens, Wiesje M. van der Flier
Přispěvatelé: Medical Psychology, APH - Personalized Medicine, APH - Quality of Care, Neurology, Radiology and nuclear medicine, Amsterdam Neuroscience - Brain Imaging, Amsterdam Neuroscience - Neuroinfection & -inflammation, Amsterdam Neuroscience - Neurodegeneration, Laboratory Medicine, Epidemiology and Data Science, APH - Methodology
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Alzheimer's & dementia : diagnosis, assessment & disease monitoring, 14(1):e12287. Elsevier BV
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 14(1):e12287. Elsevier BV
Exalto, L G, Hendriksen, H M A, Barkhof, F, van den Bosch, K A, Ebenau, J L, van Leeuwenstijn-Koopman, M, Prins, N D, Teunissen, C E, Visser, L N C, Scheltens, P & van der Flier, W M 2022, ' Subjective cognitive decline and self-reported sleep problems : The SCIENCe project ', Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, vol. 14, no. 1, e12287, pp. e12287 . https://doi.org/10.1002/dad2.12287, https://doi.org/10.1002/dad2.12287
ISSN: 2352-8729
DOI: 10.1002/dad2.12287
Popis: We aim to investigate the frequency and type of sleep problems in memory clinic patients with subjective cognitive decline (SCD) and their association with cognition, mental health, brain magnetic resonance imaging (MRI), and cerebrospinal fluid (CSF) biomarkers. Three hundred eight subjects (65 ± 8 years, 44% female) were selected from the Subjective Cognitive Impairment Cohort (SCIENCe) project. All subjects answered two sleep questionnaires, Berlin Questionnaire (sleep apnea) and Pittsburgh Sleep Quality Index (sleep quality) and underwent a standardized memory clinic work-up. One hundred ninety-eight (64%) subjects reported sleep problems, based on 107 (35%) positive screenings on sleep apnea and 162 (53%) on poor sleep quality. Subjects with sleep problems reported more severe depressive symptoms, more anxiety, and more severe SCD. Cognitive tests, MRI, and CSF biomarkers did not differ between groups. Our results suggest that improvement of sleep quality and behaviors are potential leads for treatment in many subjects with SCD to relieve the experienced cognitive complaints.
Databáze: OpenAIRE
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