Caecum location in laboratory rats and mice: an anatomical and radiological study
| Autor: | Kürşad Aytekin, Serhat Karaman, Hilal Irmak Sapmaz, Murat Uysal, Mehmet Kemal Tümer, Funda Uysal, Serdar Gül, Ufuk Taş |
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| Přispěvatelé: | Fakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Ortopedi ve Travmatoloji Ana Bilim Dalı, Aytekin, Kürşad, Uludağ Üniversitesi/Tıp Fakültesi/Fizyoloji Anabilim Dalı., Uysal, Funda |
| Rok vydání: | 2016 |
| Předmět: |
Veterinary sciences
0301 basic medicine Mouse Errors Wistar Autopsy Abdominal cavity Wistar rat Procedures Caecum Mice Cecum Bagg albino mouse Intraperitoneal injection biology digestive oral and skin physiology Anatomy Intraperitoneal drug administration medicine.anatomical_structure Injections Intraperitoneal Anatomy and histology Morphology Rotation Weterinary digestive system Injections Computed tomographic 03 medical and health sciences Quadrant (abdomen) medicine Animals Intraperitoneal Animal experiment Rats Wistar Cellulose Retro Punctures 030109 nutrition & dietetics General Veterinary Euthanasia Animal Nonhuman biology.organism_classification Rats 030104 developmental biology Organ Localization Rat Animal Science and Zoology Zoology Controlled study |
| Zdroj: | Laboratory Animals. 51:245-255 |
| ISSN: | 1758-1117 0023-6772 |
| DOI: | 10.1177/0023677216658916 |
| Popis: | Tumer, Mehmet Kemal/0000-0002-6250-0954; Uysal, Murat/0000-0003-0717-4428 WOS: 000401251400001 PubMed: 27381195 Intraperitoneal (i.p.) injection is the most frequently used method for implementing parenteral therapies in rats and mice. Whether the caecum is located in the right caudal quadrant or left caudal quadrant in the abdominal cavity is not clear. For that reason, we have developed a method for identifying the location of the caecum in rats and mice and thus revealed the most reliable location for i.p. injection in these animals. Two hundred Wistar albino rats and 100 BALB/c mice were used. The location of the caecum was determined by revealing the intra-abdominal organs immediately following euthanasia, photographing the organs, and archiving the images. Both digital photographic images and computed tomographic (CT) sections were analysed in terms of caecum morphology and location. In both rats and mice, the caecum was most commonly located on the animal's left side. It was less frequently located on the right side or in the centre. The caecum was typically comma-shaped, but it was round or S-shaped in some animals. The direction of rotation of the caecum from the basis to the apex was mostly counterclockwise. Additionally, the apex showed a tendency to be evenly centred. This study demonstrated that the caecum was mostly located on the animal's left side; and for that reason, the most suitable location for i.p. injection in these animals was understood to be the right caudal quadrant. Furthermore, when we compared the CT images and autopsy findings, the caecum did not change location in the abdominal cavity postmortem. |
| Databáze: | OpenAIRE |
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