Screening for Ames mutagenicity of food flavor chemicals by (quantitative) structure-activity relationship
| Autor: | Airi Kitazawa, Toshio Kasamatsu, Masamitsu Honma, Kei-ichi Sugiyama |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Quantitative structure–activity relationship lcsh:QH426-470 Social Psychology Environmental Science (miscellaneous) Biology Ames test 03 medical and health sciences 0302 clinical medicine Mutagenicity lcsh:QH540-549.5 Genetics Food flavor Food science skin and connective tissue diseases Food flavors Research fungi food and beverages body regions lcsh:Genetics 030104 developmental biology 030220 oncology & carcinogenesis lcsh:Ecology (quantitative) structure-activity relationship ((Q)SAR) |
| Zdroj: | Genes and Environment Genes and Environment, Vol 42, Iss 1, Pp 1-6 (2020) |
| ISSN: | 1880-7062 |
| DOI: | 10.1186/s41021-020-00171-1 |
| Popis: | Background (Quantitative) Structure-Activity Relationship ((Q)SAR) is a promising approach to predict the potential adverse effects of chemicals based on their structure without performing toxicological studies. We evaluate the mutagenicity of food flavor chemicals by (Q) SAR tools, identify potentially mutagenic chemicals, and verify their mutagenicity by actual Ames test. Results The Ames mutagenicity of 3942 food flavor chemicals was predicted using two (Q)SAR) tools, DEREK Nexus and CASE Ultra. Three thousand five hundred seventy-five chemicals (91%) were judged to be negative in both (Q) SAR tools, and 75 chemicals (2%) were predicted to be positive in both (Q) SAR tools. When the Ames test was conducted on ten of these positive chemicals, nine showed positive results. Conclusion The (Q) SAR method can be used for screening the mutagenicity of food flavors. |
| Databáze: | OpenAIRE |
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