Adrenal androgens and cortisol in major depression
| Autor: | Aleksandra Chicz-DeMet, Lawrence N. Parker, Christopher Reist, Eric Lifrak, Hadley Osran, Cheng-Chung Chen |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Adult
Male endocrine system medicine.medical_specialty Cortisol awakening response Hydrocortisone medicine.drug_class Dehydroepiandrosterone Dexamethasone Adrenocorticotropic Hormone Internal medicine medicine Humans Depression (differential diagnoses) Psychiatric Status Rating Scales Depressive Disorder Androgen Circadian Rhythm Psychiatry and Mental health Endocrinology Hypercortisolemia Psychology hormones hormone substitutes and hormone antagonists Glucocorticoid medicine.drug |
| Zdroj: | American Journal of Psychiatry. 150:806-809 |
| ISSN: | 1535-7228 0002-953X |
| DOI: | 10.1176/ajp.150.5.806 |
| Popis: | Nine depressed subjects and nine comparison subjects completed a study of abnormalities in adrenal androgen and cortisol metabolism. Serum levels of cortisol and dehydroepiandrosterone (DHA) at 8:00 a.m. and 4:00 p.m. revealed hypercortisolemia and loss of diurnal DHA variation but not cortisol variation in the depressed group. These findings suggest that in depression, adrenal androgens, in contrast to cortisol, are partially regulated by mechanisms independent of ACTH. |
| Databáze: | OpenAIRE |
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