Thyroid metastasis as initial presentation of clear cell renal carcinoma

Autor: César P. Ramírez-Plaza, Francisco Blanco-Reina, Marta E. Domínguez-López
Přispěvatelé: [Ramírez-Plaza,CP] General and Digestive Surgery Service, Hospital Quirón, Málaga, Spain. [Domínguez-López,ME] Endocrinology Service, Hospital Regional Málaga Carlos Haya, Málaga, Spain. [Blanco-Reina,F] Urology Service, Hospital Regional Málaga Carlos Haya, Málaga, Spain.
Jazyk: angličtina
Rok vydání: 2015
Předmět:
Pathology
medicine.medical_specialty
endocrine system
Diseases::Neoplasms::Neoplasms by Site::Urogenital Neoplasms::Urologic Neoplasms::Kidney Neoplasms [Medical Subject Headings]
endocrine system diseases
Neoplasias renales
Analytical
Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Imaging::Tomography::Tomography
X-Ray::Tomography
X-Ray Computed [Medical Subject Headings]
Nódulo tiroideo
Diseases::Neoplasms::Neoplasms by Site::Endocrine Gland Neoplasms::Thyroid Neoplasms [Medical Subject Headings]
Case Report
Diseases::Neoplasms::Neoplasms by Site::Endocrine Gland Neoplasms::Thyroid Neoplasms::Thyroid Nodule [Medical Subject Headings]
Metastasis
Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings]
Analytical
Diagnostic and Therapeutic Techniques and Equipment::Surgical Procedures
Operative::Biopsy [Medical Subject Headings]
Analytical
Diagnostic and Therapeutic Techniques and Equipment::Surgical Procedures
Operative::Endocrine Surgical Procedures::Thyroidectomy [Medical Subject Headings]
Analytical
Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Longitudinal Studies::Follow-Up Studies [Medical Subject Headings]
Bocio
medicine
Carcinoma
Nefrectomía
Renal
Neoplasias de la tiroides
Thyroid
Diseases::Endocrine System Diseases::Thyroid Diseases [Medical Subject Headings]
Thyroid metastasis
business.industry
Carcinoma de células renales
Anatomy::Cells::Cellular Structures::Intracellular Space::Cytoplasm::Cytoplasmic Structures::Organelles::Cytoplasmic Vesicles::Vacuoles [Medical Subject Headings]
Distant metastasis
medicine.disease
Treatment
Biopsia
Vacuolas
medicine.anatomical_structure
Check Tags::Female [Medical Subject Headings]
Analytical
Diagnostic and Therapeutic Techniques and Equipment::Surgical Procedures
Operative::Urogenital Surgical Procedures::Urologic Surgical Procedures::Nephrectomy [Medical Subject Headings]
Clear Cell Renal Carcinoma
Diseases::Neoplasms::Neoplasms by Site::Urogenital Neoplasms::Urologic Neoplasms::Kidney Neoplasms::Carcinoma
Renal Cell [Medical Subject Headings]
Surgery
Tomografía computarizada por rayos X
Estudios de seguimiento
Presentation (obstetrics)
business
Tiroidectomía
Zdroj: International Journal of Surgery Case Reports
ISSN: 2210-2612
Popis: Highlights • Thyroid metastases from other primary are exceptional. • When present, a therapeutic approach in order to cure is still feasible for the primary tumor. • Diagnosis of thyroid metastasis is difficult if not kept in mind. • Renal tumors are frequently metastatic at the time of diagnosis.
Introduction Metastatic tumors account for 1.4–2.5% of thyroid malignancies. About 25–30% of patients with clear cell renal carcinoma (CCRC) have distant metastasis at the time of diagnosis, being the thyroid gland a rare localization [5%]. Presentation of the case A 62-year woman who underwent a cervical ultrasonography and a PAAF biopsy reporting atypical follicular proliferation with a few intranuclear vacuoles “suggestive” of thyroid papillary cancer in the context of a multinodular goiter was reported. A total thyroidectomy was performed and the histology of a clear cell renal carcinoma (CCRC) was described in four nodules of the thyroid gland. A CT scan was performed and a renal giant right tumor was found. The patient underwent an eventful radical right nephrectomy and the diagnosis of CCRC was confirmed. Discussion Thyroid metastasis (TM) from CCRC are usually apparent in a metachronic context during the follow-up of a treated primary (even many years after) but may sometimes be present at the same time than the primary renal tumor. Our case is exceptional because the TM was the first evidence of the CCRC, which was subsequently diagnosed and treated. Conclusion The possibility of finding of an incidental metastatic tumor in the thyroid gland from a previous unknown and non-diganosed primary (as CCRC in our case was) is rare and account only for less than 1% of malignancies. Nonetheless, the thyroid gland is a frequent site of metastasis and the presence of “de novo” thyroid nodules in oncologic patients must be always considered and studied.
Databáze: OpenAIRE
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