| Autor: |
van den Bosch, Ruben, Lambregts, Britt, Määttä, Jessica, Hofmans, Lieke, Papadopetraki, Danae, Westbrook, Andrew, Verkes, Robbert-Jan, Booij, Jan, Cools, Roshan |
| Rok vydání: |
2022 |
| Předmět: |
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| DOI: |
10.6084/m9.figshare.19962962 |
| Popis: |
We tested the hypothesis that methylphenidate enhances or impairs reward/punishment-based reversal learning depending on baseline striatal dopamine levels and corticostriatal gating of reward/punishment-related representations in stimulus-specific sensory cortex. Young healthy adults (N=100) were scanned with functional magnetic resonance imaging (fMRI) during a reward/punishment reversal learning task, after intake of methylphenidate (20 mg) or the selective D2/3-receptor antagonist sulpiride (400 mg). Striatal dopamine synthesis capacity was indexed with [18F]DOPA positron emission tomography (PET). Both drugs boosted reward versus punishment learning signals to a greater degree in participants with higher dopamine synthesis capacity. By contrast, surprise signals in the striatum and stimulus-specific sensory cortex were boosted by the dopamine drugs in participants with lower dopamine synthesis. Methylphenidate may alter the balance between a phasic dopamine mode that promotes reward/punishment-specific learning and a tonic dopamine mode that promotes surprise-driven attention, depending on baseline dopamine synthesis capacity. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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