Cancer mortality in an international cohort of reinforced plastics workers exposed to styrene: a reanalysis

Autor: Damien McElvenny, Valerio Gennaro, Manolis Kogevinas, Henrik A Kolstad, Vincenzo Fontana, Markku Sallmén, Dana Loomis, Neela Guha, Rodolfo Saracci
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Male
Oncology
Time Factors
Esophageal Neoplasms
Epidemiology
Disease
Cohort Studies
0302 clinical medicine
Neoplasms
Medicine
Disease type
030212 general & internal medicine
Workplace
Organ system
Càncer
Cancer
030210 environmental & occupational health
Europe
Occupational Diseases
Cohort
Female
epidemiology
Plastics
Cohort study
medicine.medical_specialty
Styrenes
03 medical and health sciences
Occupational Exposure
Internal medicine
Mortalitat
Humans
Industry
cancer
Mortality
Lung cancer
Carcinogen
disease
business.industry
Public Health
Environmental and Occupational Health
medicine.disease
Pancreatic Neoplasms
disease type
Relative risk
organ system
business
Cohort Studies Esophageal Neoplasms/mortality Europe/epidemiology Female Humans Industry Male Neoplasms/*mortality Occupational Diseases/*mortality Occupational Exposure/*adverse effects Pancreatic Neoplasms/mortality Plastics Styrenes/*adverse effects Time Factors *cancer *disease *disease type *epidemiology *organ system
Zdroj: Loomis, D, Guha, N, Kogevinas, M, Fontana, V, Gennaro, V, Kolstad, H A, McElvenny, D M, Sallmen, M & Saracci, R 2019, ' Cancer mortality in an international cohort of reinforced plastics workers exposed to styrene: a reanalysis ', Occup Environ Med, vol. 76, no. 3, pp. 157-162 . https://doi.org/10.1136/oemed-2018-105131
Loomis, D, Guha, N, Kogevinas, M, Fontana, V, Gennaro, V, Kolstad, H A, McElvenny, D M, Sallmén, M & Saracci, R 2019, ' Cancer mortality in an international cohort of reinforced plastics workers exposed to styrene : A reanalysis ', Occupational and Environmental Medicine, vol. 76, no. 3, pp. 157-162 . https://doi.org/10.1136/oemed-2018-105131
Recercat. Dipósit de la Recerca de Catalunya
instname
Occupational and Environmental Medicine
Dipòsit Digital de la UB
Universidad de Barcelona
DOI: 10.1136/oemed-2018-105131
Popis: OBJECTIVE: To investigate the carcinogenicity of styrene by reanalysing data from a previous international cohort study of workers in the reinforced plastics industry. METHODS: Mortality from cancers of prior interest was analysed with more detailed consideration of exposure-response relations and an updated classification of leukaemias and lymphomas in data from a previous international cohort study of 37 021 reinforced plastics workers exposed to airborne styrene. RESULTS: Increased mortality from non-Hodgkin's lymphoma (NHL) was associated with the mean level of exposure to styrene in air (relative risk (RR) 2.31, 95% CI 1.29 to 4.12 per 100 ppm), but not with cumulative styrene exposure. Similar associations with mean exposure were observed for the oesophagus (RR 2.44, 95% CI 1.11 to 5.36 per 100 ppm) and pancreas (RR 1.89, 95% CI 1.17 to 3.09). Oesophageal cancer mortality was also associated with cumulative styrene exposure lagged 20 years (RR 1.16, 95% CI 1.03 to 1.31). No other cancer, including lung cancer, was associated with any indicator of styrene exposure. CONCLUSION: This reanalysis does not substantially change the conclusions of the original study with respect to NHL or lung cancer but new evidence concerning cancers of the oesophagus and pancreas merits further investigation.
Databáze: OpenAIRE
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